De Novo Assembly Group
The availability of large volumes of genome sequences from a variety of species has fundamentally changed our approach to experimentation, whether in the form of low coverage surveys, reference sequence assemblies or finished regions of high biological interest. The De Novo Assembly Group is responsible for taking the sequenced pieces of the genome and putting them together as contiguously and accurately as possible, analogous to putting together pieces of a puzzle to make a picture clear and complete. In addition, we are responsible for creating de novo assemblies of tissue specific transcriptomes for numerous species. As a result of our efforts we have generated draft assemblies of numerous species from the low complexity microbes to highly evolved primates.
Today we face challenges in obtaining accurate assemblies from next generation sequencing platforms. These new sequencing methods produce significantly higher read numbers with shorter read lengths, while drastically reducing costs. Our group continues to test newly developed assembly algorithms with the promise of resolving the dilemma of obtaining high quality draft assemblies at low cost.
Contacts
| Name | Affiliation | |
| Wes Warren | The Genome Institute, Washington University School of Medicine | Send Email |
Activities
