Lucinda Fulton
Research Accomplishments & Interests
Lucinda Fulton attended Southern Illinois University Edwardsville (SIUE), where she received an MS degree and shortly thereafter joined Washington University as part of a team working to sequence the C. elegans genome. During her time at the university, she has watched the sequencing project grow from a team of 7 individuals to well over 300 employees. Early in her career she worked as a technician in the production team, and later as a finisher. These experiences provided a solid foundation and real world understanding of production sequencing challenges. In 1996, she became the leader of the library construction group and continued to serve as a resource for the production teams. In 1999, she was named the Assistant Group Leader for Production and in 2002 became Group Leader. Under her direction, and with the help of her colleagues, the production pipeline now produces several thousand gigabases of sequence per month. Sequencing efforts at The Genome Institute now include whole genome shotgun production and targeted re-sequencing of human and other organism-based samples. With the advent of larger numbers of human DNA samples in the pipeline, Ms. Fulton has worked with her colleagues to design a robust incoming sample review and documentation process that ensures only qualified samples are selected for sequencing. She enjoys working closely with other members of the senior staff as well as her team of dedicated production mangers to find unique and innovative solutions to the challenges she encounters.
Selected Publications
Iossifov I, Ronemus M, Levy D, Wang Z, Hakker I, Rosenbaum J, Yamrom B, Lee…
De novo gene disruptions in children on the autistic spectrum.
Neuron. 2012 Apr 26;74(2):285-99. PubMed | View Abstract
Ding L, Ley TJ, Larson DE, Miller CA, Koboldt DC, Welch JS, Ritchey JK, Young…
Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing.
Nature. 2012 Jan 11. doi: 10.1038/nature10738. [Epub ahead of print] PubMed | View Abstract
Zhang J, Ding L, Holmfeldt L, Wu G, Heatley SL, Payne-Turner D, Easton J, Chen…
The genetic basis of early T-cell precursor acute lymphoblastic leukaemia.
Nature. 2012 Jan 11;481(7380):157-63. doi: 10.1038/nature10725. PubMed | View Abstract
Zhang J, Benavente CA, McEvoy J, Flores-Otero J, Ding L, Chen X, Ulyanov A, Wu…
A novel retinoblastoma therapy from genomic and epigenetic analyses.
Nature. 2012 Jan 11. doi: 10.1038/nature10733. [Epub ahead of print] PubMed | View Abstract
Lindblad-Toh K, Garber M, Zuk O, Lin MF, Parker BJ, Washietl S, Kheradpour P, Ernst…
A high-resolution map of human evolutionary constraint using 29 mammals.
Nature. 2011 Oct 12;478(7370):476-82. doi: 10.1038/nature10530. PubMed | View Abstract
Marth GT, Yu F, Indap AR, Garimella K, Gravel S, Leong WF, Tyler-Smith C, Bainbridge…
The functional spectrum of low-frequency coding variation.
Genome Biol. 2011 Sep 14;12(9):R84. [Epub ahead of print] PubMed | View Abstract
Gravel S, Henn BM, Gutenkunst RN, Indap AR, Marth GT, Clark AG, Yu F, Gibbs…
Demographic history and rare allele sharing among human populations.
Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):11983-11988. Epub 2011 Jul 5. PubMed | View Abstract
Church DM, Schneider VA, Graves T, Auger K, Cunningham F, Bouk N, Chen HC, Agarwala…
Modernizing reference genome assemblies.
PLoS Biol. 2011 Jul;9(7):e1001091. Epub 2011 Jul 5. PubMed | View Abstract
The Cancer Genome Atlas Research Network
Integrated genomic analyses of ovarian carcinoma
Nature. 2011 Jun 29;474(7353):609-15. doi: 10.1038/nature10166. PubMed | View Abstract
The 1000 Genomes Project, Conrad DF, Keebler JE, Depristo MA, Lindsay SJ, Zhang Y, Casals…
Variation in genome-wide mutation rates within and between human families.
Nat Genet. 2011 Jun 12;43(7):712-714. doi: 10.1038/ng.862. PubMed | View Abstract
Link DC, Schuettpelz LG, Shen D, Wang J, Walter MJ, Kulkarni S, Payton JE, Ivanovich…
Identification of a Novel TP53 Cancer Susceptibility Mutation Through Whole-Genome Sequencing of a Patient With Therapy-Related AML
JAMA. 2011 Apr 20;305(15):1568-1576. PubMed | View Abstract
Mitreva M, Jasmer DP, Zarlenga DS, Wang Z, Abubucker S, Martin J, Taylor CM, Yin…
The draft genome of the parasitic nematode Trichinella spiralis
Nature Genetics 2011 doi:10.1038/ng.769 PubMed | View Abstract
Mills RE, Walter K, Stewart C, Handsaker RE, Chen K, Alkan C, Abyzov A, Yoon…
Mapping copy number variation by population-scale genome sequencing.
Nature. 2011 Feb 3;470(7332):59-65. PubMed | View Abstract
Locke DP, Hillier LW, Warren WC, Worley KC, Nazareth LV, Muzny DM, Yang SP, Wang…
Comparative and demographic analysis of orang-utan genomes
Nature. 2011 Jan 27;469(7331):529-33. PubMed | View Abstract
Baxter L, Tripathy S, Ishaque N, Boot N, Cabral A, Kemen E, Thines M, Ah-Fong…
Signatures of adaptation to obligate biotrophy in the Hyaloperonospora arabidopsidis genome.
Science. 2010 Dec 10;330(6010):1549-51. PubMed | View Abstract
