LaDeana Hillier
Research Accomplishments & Interests
Dr. LaDeana Hillier is an Assistant Director at The Genome Institute and Senior Research Scientist in the Department of Genetics at Washington University School of Medicine, joining the department in 1989. She has been with The Genome Institute since its inception. As Assistant Director of Informatics she has been responsible for all aspects of computational support for lab activities, user support and education, sequence analysis, submission of data to public repositories, grant preparation and publication. She has participated in software design, human sequence analysis and the sequence and analysis of various model genomes, including C. elegans, the mouse, chicken, chimpanzee and various plants and other animals.
As a participant in the Human Genome Project, Dr. Hillier was responsible for software, automation, analysis, networks and systems for the lab and played a key role in the development of the physical map of the genome. She was also responsible for the consolidation of the physical map and all genetic mapping data and existing sequence data to help maintain a non-redundant path through the genome. She supplied clones to all of the labs around the world sequencing the human genome, and helped with the interpretation of the resulting analyses. Her lab has also been responsible for helping to "finish" the human genome sequence, filling in gaps in unknown regions. Her current primary research interests are in integration of sequence and mapping data and in large-scale comparative genomic analysis. She continues to aid in the development of new methods for sequencing and analyzing genomes.
Selected Publications
Scally A, Dutheil JY, Hillier LW, Jordan GE, Goodhead I, Herrero J, Hobolth A, Lappalainen…
Insights into hominid evolution from the gorilla genome sequence.
Nature. 2012 Mar 7;483(7388):169-75. doi: 10.1038/nature10842. PubMed | View Abstract
Ye L, Hillier LW, Minx P, Thane N, Locke D, Martin JC, Chen L, Mitreva…
A vertebrate case study of the quality of assemblies derived from next-generation sequences.
Genome Biol. 2011 Mar 31;12(3):R31. [Epub ahead of print] PubMed | View Abstract
Locke DP, Hillier LW, Warren WC, Worley KC, Nazareth LV, Muzny DM, Yang SP, Wang…
Comparative and demographic analysis of orang-utan genomes
Nature. 2011 Jan 27;469(7331):529-33. PubMed | View Abstract
Meader S, Hillier LW, Locke D, Ponting CP, Lunter G.
Genome assembly quality: assessment and improvement using the neutral indel model.
Genome Res. 2010 May;20(5):675-84. Epub 2010 Mar 19. PubMed | View Abstract
Warren WC, Clayton DF, Ellegren H, Arnold AP, Hillier LW, Künstner A, Searle S, White…
The genome of a songbird.
Nature. 2010 Apr 1;464(7289):757-62. PubMed | View Abstract
Marques-Bonet T, Kidd JM, Ventura M, Graves TA, Cheng Z, Hillier LW, Jiang Z, Baker…
A burst of segmental duplications in the genome of the African great ape ancestor.
Nature. 2009 Feb 12;457(7231):877-81. PubMed | View Abstract
Ley TJ, Mardis ER, Ding L, Fulton B, McLellan MD, Chen K, Dooling D, Dunford-Shore…
DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome.
Nature. 2008 Nov 6;456(7218):66-72. PubMed | View Abstract
Zody MC, Jiang Z, Fung HC, Antonacci F, Hillier LW, Cardone MF, Graves TA, Kidd…
Evolutionary toggling of the MAPT 17q21.31 inversion region.
Nat Genet. 2008 Aug 10. [Epub ahead of print] PubMed | View Abstract
Ordoñez GR, Hillier LW, Warren WC, Grützner F, López-Otín C, Puente XS.
Loss of genes implicated in gastric function during platypus evolution.
Genome Biol. 2008;9(5):R81. Epub 2008 May 15. PubMed | View Abstract
Warren WC, Hillier LW, Marshall Graves JA, Birney E, Ponting CP, Grützner F, Belov K,…
Genome analysis of the platypus reveals unique signatures of evolution.
Nature. 2008 May 8;453(7192):175-83. PubMed | View Abstract
Hillier LW, Marth GT, Quinlan AR, Dooling D, Fewell G, Barnett D, Fox P, Glasscock…
Whole-genome sequencing and variant discovery in C. elegans.
Nat Methods. 2008 Feb;5(2):183-8. Epub 2008 Jan 20. PubMed | View Abstract
Drosophila 12 Genomes Consortium; Project Leaders, Clark AG, Eisen MB, Smith DR, Bergman CM, Oliver…
Evolution of genes and genomes on the Drosophila phylogeny.
Nature. 2007 Nov 8;450(7167):203-218. PubMed | View Abstract
Wendl MC, Smith S, Pohl CS, Dooling DJ, Chinwalla AT, Crouse K, Hepler T, Leong…
Design and implementation of a generalized laboratory data model.
BMC Bioinformatics. 2007 Sep 26;8(1):362 [Epub ahead of print] PubMed | View Abstract
Hillier LW, Miller RD, Baird SE, Chinwalla A, Fulton LA, Koboldt DC, Waterston RH.
Comparison of C. elegans and C. briggsae Genome Sequences Reveals Extensive Conservation of Chromosome Organization and Synteny.
PLoS Biol. 2007 Jul 3;5(7):e167 [Epub ahead of print] PubMed | View Abstract
Rhesus Macaque Genome Sequencing and Analysis Consortium, Gibbs RA, Rogers J, Katze MG, Bumgarner R,…
Evolutionary and biomedical insights from the rhesus macaque genome.
Science. 2007 Apr 13;316(5822):222-34. PubMed | View Abstract
