Adam E. Locke, Ph.D.,  McDonnell Genome Institute

Dr. Adam Locke is Assistant Professor of Medicine. Dr. Locke's primary research focus is using genomics approaches to identify genes predisposing to common, complex human diseases. His work focuses on traits relevant to metabolic and cardiovascular disease risk, particularly the genetic contributions to obesity and type 2 diabetes. Dr. Locke has also been a leader in the analysis of large-scale exome and whole genome sequencing studies for type 2 diabetes, quantitative measures of cardiovascular and metabolic disease, and psychiatric disorders. In addition to gene discovery efforts, Dr. Locke is interested in using functional genomics to determine the pathophysiological mechanisms underlying genetic associations to complex disease.

Before coming to Washington University, Dr. Locke was a post-doctoral fellow with Dr. Michael Boehnke in the Center for Statistical Genetics (Department of Biostatistics) at the University of Michigan from 2011-2015. In 2010, he earned his Ph.D. (Genetics & Molecular Biology) from Emory University in the labs of Drs. Stephanie Sherman and Michael Zwick, where he earned an American Heart Association Pre-doctoral Fellowship for his studies on the genetic contributions to congenital heart defects in individuals with Down Syndrome. He earned his B.A. in Biology from Lawrence University in 2003.


title citation publication date
Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study PLoS Genet. 2017 Oct 30;13(10):e1007079. doi: 10.1371/journal.pgen.1007079. eCollection 2017 Oct. 1970-08-22
Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits. Am J Hum Genet. 2017 Jun 1;100(6):865-884. doi: 10.1016/j.ajhg.2017.04.014. Epub 2017 May 25. 1970-08-22
Rare and low-frequency coding variants alter human adult height Nature. 2017 Feb 9;542(7640):186-190. doi: 10.1038/nature21039. Epub 2017 Feb 1. 2017-02-09
Avian W and mammalian Y chromosomes convergently retained dosage-sensitive regulators. Nat Genet. 2017 Jan 30. doi: 10.1038/ng.3778. [Epub ahead of print] 1970-08-22