Cherilynn Shadding, Ph.D.,  McDonnell Genome Institute

Research Accomplishments & Interests

Cherilynn Reynolds Shadding, Ph.D., serves as the Outreach Director for the McDonnell Genome Institute, a position she has held since 2006. In this position, she is responsible for designing, implementing, and maintaining genomics education programs for the community at large and for K-12 and undergraduate students that stimulate their interest in careers in genomics related fields. Through her leadership, Opportunities in Genomics Research (OGR) was launched in 2007. This program seeks to increase the number of underrepresented minorities who obtain Ph.D.s in the field of genomics/genetics. To date, two programs have been implemented under OGR, Undergraduate Scholars and Extensive Study. Dr. Shadding is currently involved in research that seeks to identify the interventions that encourage minority students to pursue careers in STEM (science, technology, engineering, mathematics).

Other Biographical Information

Dr. Shadding received her BA (1995) and MA (1998) in Biology at Fisk University in Nashville. She attended graduate school at Meharry Medical College, where she earned her Ph.D. (2002) in Physiology. Her research focus was cell signaling mechanisms in vascular smooth muscle cells and how such events may lead to vascular disease. After receiving her Ph.D, she completed a postdoctoral fellowship at the National Institute on Aging–National Institutes of Health in Baltimore, MD, under Dr. Rui-Ping Xiao. She conducted research that examined the effects of referfusion/injury, hypoxia and acidosis induced signaling pathways in cardiomyoctyes. She did a second postdoctoral fellowship under Dr. Daniel Link at Washington University in St Louis, Department of Internal Medicine/Division of Oncology. She studied angiogenesis and hematopoietic stem cell recruitment to sites of injury in a mouse model of hindlimb ischemia.

Selected Publications

Zheng, M., Reynolds C., Jo, S.H, Wersto, R., Han, Q., Xiao, R.P.
Intracellular acidosis-activated p38 MAPK signaling and its essential role in cardiomyocyte ischemia.
FASEB J. 19: 109-111, 2004. *co-first authors

Motley, E.D., Eguchi, K., Gardner, C., Hicks, A.L., Reynolds, C.M., Frank, G.D., Mifune, M., Ohba, M., Eguchi, S.
Insulin-induced Akt activation is inhibited by angiotensin II in the vasculature through protein kinase C-a.
Hypertension. 41[part 2]: 775-780, 2003.

Gardner, C.D., Eguchi, S., Reynolds, C.M., Eguchi, K., Frank, G.D., Motley, E.D.
Hydrogen peroxide inhibits insulin signaling in vascular smooth muscle cells.
Exp Biol Med. 228: 836-842, 2003.

Reynolds, C.M., Eguchi, S., Frank, G.D., and Motley, E.D.
Signaling mechanisms of heparin-binding EGF-like growth factor in vascular smooth muscle cells.
Hypertension. 39[part 2]: 525-529, 2002.

Publications

title citation publication date
Cost-Effective Recruitment Strategies That Attract Underrepresented Minority Undergraduates Who Persist to STEM Doctorates SAGE Open. 2016 Jul 15. DOI: 10.1177/2158244016657143 2016-07-15