Lucinda Fulton,  McDonnell Genome Institute

Research Accomplishments & Interests

Lucinda Fulton attended Southern Illinois University Edwardsville (SIUE), where she received an MS degree and shortly thereafter joined Washington University as part of a team working to sequence the C. elegans genome. During her time at the university, she has watched the sequencing project grow from a team of 7 individuals to well over 300 employees. Early in her career she worked as a technician in the production team, and later as a finisher. These experiences provided a solid foundation and real world understanding of production sequencing challenges. In 1996, she became the leader of the library construction group and continued to serve as a resource for the production teams. In 1999, she was named the Assistant Group Leader for Production and in 2002 became Group Leader. Under her direction, and with the help of her colleagues, the production pipeline now produces several thousand gigabases of sequence per month. Sequencing efforts at the McDonnell Genome Institute now include whole genome shotgun production and targeted re-sequencing of human and other organism-based samples. With the advent of larger numbers of human DNA samples in the pipeline, Ms. Fulton has worked with her colleagues to design a robust incoming sample review and documentation process that ensures only qualified samples are selected for sequencing. She enjoys working closely with other members of the senior staff as well as her team of dedicated production mangers to find unique and innovative solutions to the challenges she encounters.

Publications

title citation publication date
Integrated genomic characterization of oesophageal carcinoma. Nature. 2017 Jan 12;541(7636):169-175. doi: 10.1038/nature20805. Epub 2017 Jan 4. 1970-08-22
Integrated genomic and molecular characterization of cervical cancer. Nature. 2017 Jan 23. doi: 10.1038/nature21386. [Epub ahead of print] 1970-08-22
The role of rare protein-coding variants to anti-TNF treatment response in rheumatoid arthritis. Arthritis Rheumatol. 2016 Oct 27. doi: 10.1002/art.39966. [Epub ahead of print] 2016-10-24
Deregulation of DUX4 and ERG in acute lymphoblastic leukemia. Nat Genet. 2016 Oct 24. doi: 10.1038/ng.3691. [Epub ahead of print] 1970-08-22
The genomic landscape of core-binding factor acute myeloid leukemias Nat Genet. 2016 Oct 31. doi: 10.1038/ng.3709. [Epub ahead of print] 1970-08-22
Opsin Repertoire and Expression Patterns in Horseshoe Crabs: Evidence from the Genome of Limulus polyphemus (Arthropoda: Chelicerata) Genome Biol Evol. 2016 Jun 3;8(5):1571-89. doi: 10.1093/gbe/evw100. 2016-06-03
The Physarum polycephalum Genome Reveals Extensive Use of Prokaryotic Two-component and Metazoan-type Tyrosine Kinase Signaling. Genome Biol Evol. 2015 Nov 27. pii: evv237. [Epub ahead of print] 2015-11-27
Genome of Rhodnius prolixus, an insect vector of Chagas disease, reveals unique adaptations to hematophagy and parasite infection. Proc Natl Acad Sci U S A. 2015 Dec 1;112(48):14936-14941. Epub 2015 Nov 16. 2015-12-01
A global reference for human genetic variation. Nature. 2015 Oct 1;526(7571):68-74. doi: 10.1038/nature15393. 2015-10-01
Extreme selective sweeps independently targeted the X chromosomes of the great apes. Proc Natl Acad Sci U S A. 2015 May 19;112(20):6413-8. doi: 10.1073/pnas.1419306112. Epub 2015 May 4. 2015-05-19
TYK2 Protein-Coding Variants Protect against Rheumatoid Arthritis and Autoimmunity, with No Evidence of Major Pleiotropic Effects on Non-Autoimmune Complex Traits. PLoS One. 2015 Apr 7;10(4):e0122271. doi: 10.1371/journal.pone.0122271. eCollection 2015. 2015-04-07
Sequencing the mouse y chromosome reveals convergent gene acquisition and amplification on both sex chromosomes. Cell. 2014 Nov 6;159(4):800-13. doi: 10.1016/j.cell.2014.09.052. Epub 2014 Oct 30. 2014-11-06
Whole Genome Sequence of the Treponema pallidum subsp. endemicum Strain Bosnia A: The Genome Is Related to Yaws Treponemes but Contains Few Loci Similar to Syphilis Treponemes. PLoS Negl Trop Dis. 2014 Nov 6;8(11):e3261. doi: 10.1371/journal.pntd.0003261. eCollection 2014. 2014-11-06
Gibbon genome and the fast karyotype evolution of small apes. Nature. 2014 Sep 11;513(7517):195-201. doi: 10.1038/nature13679. 2014-09-11
C11orf95-rela fusions drive oncogenic NF-kb signaling in ependymoma. Neuro Oncol. 2014 Jul;16 Suppl 3:iii16. doi: 10.1093/neuonc/nou206.57. 2014-07-01
Comprehensive molecular profiling of lung adenocarcinoma. Nature. 2014 Jul 31;511(7511):543-50. doi: 10.1038/nature13385. Epub 2014 Jul 9. 2014-07-09
The common marmoset genome provides insight into primate biology and evolution. Nat Genet. 2014 Jul 20. doi: 10.1038/ng.3042. [Epub ahead of print] 2014-07-20
Clonal architecture of secondary acute myeloid leukemia defined by single-cell sequencing. PLoS Genet. 2014 Jul 10;10(7):e1004462. doi: 10.1371/journal.pgen.1004462. eCollection 2014. 2014-07-10
Draft Genome Sequence of Acetobacter aceti Strain 1023, a Vinegar Factory Isolate. Genome Announc. 2014 Jun 5;2(3). pii: e00550-14. doi: 10.1128/genomeA.00550-14. 2014-06-05
The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma. Nat Genet. 2014 May;46(5):444-50. doi: 10.1038/ng.2938. Epub 2014 Apr 6. 2014-05-01
C11orf95-RELA fusions drive oncogenic NF-kappaB signalling in ependymoma. Nature. 2014 Feb 27;506(7489):451-5. doi: 10.1038/nature13109. Epub 2014 Feb 19. 2014-02-27
RB1 gene inactivation by chromothripsis in human retinoblastoma. Oncotarget. 2014 Jan 11. [Epub ahead of print] 2014-01-11
Re-sequencing Expands Our Understanding of the Phenotypic Impact of Variants at GWAS Loci. PLoS Genet. 2014 Jan 30;10(1):e1004147. doi: 10.1371/journal.pgen.1004147. eCollection 2014. 2014-01-30
Integrative annotation of variants from 1092 humans: application to cancer genomics. Science. 2013 Oct 4;342(6154):1235587. doi: 10.1126/science.1235587. 2013-10-04
The Somatic Genomic Landscape of Glioblastoma. Cell. 2013 Oct 10;155(2):462-477. doi: 10.1016/j.cell.2013.09.034. 2013-10-10
The Cancer Genome Atlas Pan-Cancer analysis project. Nat Genet. 2013 Sep 26;45(10):1113-20. doi: 10.1038/ng.2764. 2013-09-26
Identification of a rare coding variant in complement 3 associated with age-related macular degeneration. Nat Genet. 2013 Sep 15. doi: 10.1038/ng.2758. [Epub ahead of print] 2013-09-15
The human genome: genes, pseudogenes, and variation on chromosome 7. Cold Spring Harb Symp Quant Biol. 2003;68:13-22. 2003-01-01
Rates and patterns of great ape retrotransposition. Proc Natl Acad Sci U S A. 2013 Jul 24. [Epub ahead of print] 2013-07-24
Mutational profiling in the human genome. Cold Spring Harb Symp Quant Biol. 2003;68:23-9. 2003-01-01
Toward sequencing the sorghum genome. A U.S. National Science Foundation-sponsored workshop report. Plant Physiol. 2005 Aug;138(4):1898-902. 2005-08-01
Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Nature. 1999 Dec 16;402(6763):769-77. 1998-12-16
The genome of the nematode Caenorhabditis elegans. Cold Spring Harb Symp Quant Biol. 1993;58:367-76. 1993-01-01
Great ape genetic diversity and population history. Nature. 2013 Jul 3. doi: 10.1038/nature12228. [Epub ahead of print] 2013-07-03
Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia. N Engl J Med. 2013 May 1. [Epub ahead of print] 2013-05-01
Integrated genomic characterization of endometrial carcinoma. Nature. 2013 May 2;497(7447):67-73. doi: 10.1038/nature12113. 2013-05-02
Whole genome sequence of the treponema fribourg-blanc: unspecified simian isolate is highly similar to the yaws subspecies. PLoS Negl Trop Dis. 2013 Apr 18;7(4):e2172. doi: 10.1371/journal.pntd.0002172. Print 2013 Apr. 2013-04-18
Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas. Nat Genet. 2013 Apr 14. doi: 10.1038/ng.2611. [Epub ahead of print] 2013-04-14
The western painted turtle genome, a model for the evolution of extreme physiological adaptations in a slowly evolving lineage. Genome Biol. 2013 Mar 28;14(3):R28. [Epub ahead of print] 2013-03-18
Lineage-specific biology revealed by a finished genome assembly of the mouse. PLoS Biol. 2009 May 5;7(5):e1000112. doi: 10.1371/journal.pbio.1000112. Epub 2009 May 26. 2009-05-05
Sequencing of the sea lamprey (Petromyzon marinus) genome provides insights into vertebrate evolution. Nat Genet. 2013 Feb 24. doi: 10.1038/ng.2568. [Epub ahead of print] 2013-02-24
The genomic landscape of hypodiploid acute lymphoblastic leukemia. Nat Genet. 2013 Jan 20. doi: 10.1038/ng.2532. [Epub ahead of print] 2013-01-20
Somatic neurofibromatosis type 1 (NF1) inactivation characterizes NF1-associated pilocytic astrocytoma. Genome Res. 2012 Dec 5. [Epub ahead of print] 2012-12-05
An integrated map of genetic variation from 1,092 human genomes. Nature. 2012 Nov 1;491(7422):56-65. doi: 10.1038/nature11632. 2012-11-01
Comprehensive molecular portraits of human breast tumours. Nature. 2012 Sep 23. doi: 10.1038/nature11412. [Epub ahead of print] 2012-09-23
Genomic Landscape of Non-Small Cell Lung Cancer in Smokers and Never-Smokers Cell. 2012 Sep 14;150(6):1121-34. doi: 10.1016/j.cell.2012.08.024. 2012-09-14
Evaluation of 16S rDNA-Based Community Profiling for Human Microbiome Research PLoS One. 2012;7(6):e39315. Epub 2012 Jun 13. 2012-06-13
Whole-genome analysis informs breast cancer response to aromatase inhibition. Nature. 2012 Jun 10;486(7403):353-60. doi: 10.1038/nature11143. 2012-06-10
The origin and evolution of mutations in acute myeloid leukemia. Cell. 2012 Jul 20;150(2):264-78. 2012-07-20
The 1000 Genomes Project: data management and community access. Nat Methods. 2012 Apr 27;9(5):459-62. doi: 10.1038/nmeth.1974. 2012-04-27
Comprehensive molecular characterization of human colon and rectal cancer. Nature. 2012 Jul 18;487(7407):330-7. doi: 10.1038/nature11252. 2012-07-18
Novel mutations target distinct subgroups of medulloblastoma. Nature. 2012 Jun 20. doi: 10.1038/nature11213. [Epub ahead of print] 2012-06-20
A framework for human microbiome research. Nature. 2012 Jun 13;486(7402):215-21. doi: 10.1038/nature11209. 2012-06-13
Structure, function and diversity of the healthy human microbiome. Nature. 2012 Jun 13;486(7402):207-14. doi: 10.1038/nature11234. 2012-06-13
De novo gene disruptions in children on the autistic spectrum. Neuron. 2012 Apr 26;74(2):285-99. 2012-04-26
Whole genome sequences of three Treponema pallidum ssp. pertenue strains: yaws and syphilis treponemes differ in less than 0.2% of the genome sequence. PLoS Negl Trop Dis. 2012 Jan;6(1):e1471. doi: 10.1371/journal.pntd.0001471. Epub 2012 Jan 24. 2012-01-24
Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing. Nature. 2012 Jan 11. doi: 10.1038/nature10738. [Epub ahead of print] 2012-01-11
The genetic basis of early T-cell precursor acute lymphoblastic leukaemia. Nature. 2012 Jan 11;481(7380):157-63. doi: 10.1038/nature10725. 2012-01-11
A novel retinoblastoma therapy from genomic and epigenetic analyses. Nature. 2012 Jan 11. doi: 10.1038/nature10733. [Epub ahead of print] 2012-01-11
The functional spectrum of low-frequency coding variation. Genome Biol. 2011 Sep 14;12(9):R84. [Epub ahead of print] 2011-09-14
A high-resolution map of human evolutionary constraint using 29 mammals. Nature. 2011 Oct 12;478(7370):476-82. doi: 10.1038/nature10530. 2011-10-12
Evolution of symbiotic bacteria in the distal human intestine. PLoS Biol. 2007 Jul;5(7):e156. Epub 2007 Jun 19. 2007-06-19
Variation in genome-wide mutation rates within and between human families. Nat Genet. 2011 Jun 12;43(7):712-714. doi: 10.1038/ng.862. 2011-06-12
Demographic history and rare allele sharing among human populations. Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):11983-11988. Epub 2011 Jul 5. 2011-07-19
Modernizing reference genome assemblies. PLoS Biol. 2011 Jul;9(7):e1001091. Epub 2011 Jul 5. 2011-07-05
Integrated genomic analyses of ovarian carcinoma Nature. 2011 Jun 29;474(7353):609-15. doi: 10.1038/nature10166. 2011-06-29
Identification of a Novel TP53 Cancer Susceptibility Mutation Through Whole-Genome Sequencing of a Patient With Therapy-Related AML JAMA. 2011 Apr 20;305(15):1568-1576. 2011-04-20
The draft genome of the parasitic nematode Trichinella spiralis Nat Genet. 2011 Mar;43(3):228-35. Epub 2011 Feb 20. 2011-02-20
Mapping copy number variation by population-scale genome sequencing. Nature. 2011 Feb 3;470(7332):59-65. 2011-02-03
Signatures of adaptation to obligate biotrophy in the Hyaloperonospora arabidopsidis genome. Science. 2010 Dec 10;330(6010):1549-51. 2010-12-10
Comparative and demographic analysis of orang-utan genomes Nature. 2011 Jan 27;469(7331):529-33. 2011-01-27
Diversity of human copy number variation and multicopy genes. Science. 2010 Oct 29;330(6004):641-6. 2010-10-29
DNMT3A Mutations in Acute Myeloid Leukemia N Engl J Med. 2010 Nov 10. 2010-11-10
A map of human genome variation from population-scale sequencing Nature. 2010 Oct 28;467(7319):1050-1. 2010-10-28
Widespread Divergence Between Incipient Anopheles gambiae Species Revealed by Whole Genome Sequences. Science. 2010 Oct 22;330(6003):512-4. 2010-10-22
Genome sequence of Cronobacter sakazakii BAA-894 and comparative genomic hybridization analysis with other Cronobacter species. PLoS One. 2010 Mar 8;5(3):e9556. 2010-03-08
A Catalog of Reference Genomes from the Human Microbiome. Science. 2010 May 21;328(5981):994-999. 2010-05-21
The genome of a songbird. Nature. 2010 Apr 1;464(7289):757-62. 2010-04-01
Genome remodelling in a basal-like breast cancer metastasis and xenograft. Nature. 2010 Apr 15;464(7291):989-90. 2010-04-15
Detailed analysis of a contiguous 22-Mb region of the maize genome. PLoS Genet. 2009 Nov;5(11):e1000728. Epub 2009 Nov 20. 2009-11-20
The B73 maize genome: complexity, diversity, and dynamics. Science. 2009 Nov 20;326(5956):1112-5. 2009-11-20
Recurring mutations found by sequencing an acute myeloid leukemia genome. N Engl J Med. 2009 Sep 10;361(11):1058-66. Epub 2009 Aug 5. 2009-09-10
Comparative Analysis and Functional Annotation of a Large Expressed Sequence Tag Collection of Apple. The Plant Genome. 2009 March:2:23-38. 2009-03-01
A burst of segmental duplications in the genome of the African great ape ancestor. Nature. 2009 Feb 12;457(7231):877-81. 2009-02-12
Sequencing human-gibbon breakpoints of synteny reveals mosaic new insertions at rearrangement sites. Genome Res. 2008 Nov 24. [Epub ahead of print] 2008-11-24
DNA sequencing of a cytogenetically normal acute myeloid leukaemia (AML) genome. Nature. 2008 Nov 6;456(7218):66-72. 2008-11-06
Somatic mutations affect key pathways in lung adenocarcinoma. Nature. 2008 Oct 23;455(7216):1069-75. 2008-10-23
Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature. 2008 Oct 23;455(7216):1061-8. Epub 2008 Sep 4. 2008-10-23
The Pristionchus pacificus genome provides a unique perspective on nematode lifestyle and parasitism. Nat Genet. 2008 Oct;40(10):1193-8. Epub 2008 Sep 21. 2008-10-01
Genome analysis of the platypus reveals unique signatures of evolution. Nature. 2008 May 8;453(7192):175-83. 2008-05-08
Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome. Cell Host Microbe. 2008 Apr 17;3(4):213-23. 2008-04-08
The canine hookworm genome: analysis and classification of Ancylostoma caninum survey sequences. Mol Biochem Parasitol. 2008 Feb;157(2):187-92. Epub 2007 Nov 9. 2008-02-15
Evolution of genes and genomes on the Drosophila phylogeny. Nature. 2007 Nov 8;450(7167):203-218. 2007-11-08
Comprehensive genetic variant discovery in the surfactant protein B gene. Pediatr Res. 2007 Aug;62(2):170-5. 2007-08-12
Human genome ultraconserved elements are ultraselected. Science. 2007 Aug 17;317(5840):915. 2007-08-17
A second generation human haplotype map of over 3.1 million SNPs. Nature. 2007 Oct 18;449(7164):851-61. 2007-10-18
Genome-wide detection and characterization of positive selection in human populations. Nature. 2007 Oct 18;449(7164):913-8. 2007-10-18
Comparison of C. elegans and C. briggsae Genome Sequences Reveals Extensive Conservation of Chromosome Organization and Synteny. PLoS Biol. 2007 Jul 3;5(7):e167 [Epub ahead of print] 2007-07-03
Evolutionary and biomedical insights from the rhesus macaque genome. Science. 2007 Apr 13;316(5822):222-34. 2007-04-13
Mutational Analysis of EGFR and Related Signaling Pathway Genes in Lung Adenocarcinomas Identifies a Novel Somatic Kinase Domain Mutation in FGFR4 PLoS ONE. 2007 May 9;2:e426. 2007-05-09
The complete genome sequence of a chronic atrophic gastritis Helicobacter pylori strain: evolution during disease progression. Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9999-10004. Epub 2006 Jun 20.Click here to read 2006-06-27
Initial sequence of the chimpanzee genome and comparison with the human genome Nature. 2005 Sep 1;437(7055):69-87. 2005-09-01
EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13306-11. 2004-09-07
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature. 2005 Apr 7;434(7034):724-31. 2005-04-07
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Comparative genomic sequence analysis of the human and mouse cystic fibrosis transmembrane conductance regulator genes. Proc Natl Acad Sci U S A. 2000 Feb 1;97(3):1172-7. 2000-02-01
The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. Nature. 2003 Jun 19;423(6942):825-37. 2003-06-19
The Genome Sequence of Caenorhabditis briggsae: A Platform for Comparative Genomics. PLoS Biol. 2003 Nov;1(2):E45. Epub 2003 Nov 17. 2003-11-01
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Surveying Saccharomyces genomes to identify functional elements by comparative DNA sequence analysis. Genome Res. 2001 Jul;11(7):1175-86. 2001-07-01
Finding functional features in Saccharomyces genomes by phylogenetic footprinting. Science. 2003 Jul 4;301(5629):71-6. Epub 2003 May 29. 2003-06-04
The DNA sequence of human chromosome 7. Nature. 2003 Jul 10;424(6945):157-64. 2003-07-10
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Genome sequence of the nematode C. elegans: a platform for investigating biology. The C. elegans Sequencing Consortium. Science. 1998 Dec 11;282(5396):2012-8. Review. Erratum in: Science 1999 Jan 1;283(5398):35. Science 1999 Mar 26;283(5410):2103. Science 1999 Sep 3;285(5433):1493. 1998-12-10
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Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution Nature. 2004 Dec 9;432(7018):695-716. 2004-12-10
Comparison of genome degradation in Paratyphi A and Typhi, human-restricted serovars of Salmonella enterica that cause typhoid Nat Genet. 2004 Dec;36(12):1268-74. Epub 2004 Dec. 2004-11-07
Finishing the euchromatic sequence of the human genome Nature. 2004 Oct 21;431(7011):931-45. 2004-10-21
The DNA sequence and analysis of human chromosome 14. Nature. 2003 Feb 6;421(6923):601-7. Epub 2003 Jan 01. 2003-02-06