Richard K. Wilson, Ph.D.,  The Genome Institute

Dr. Wilson is an expert in molecular genetics and large-scale DNA sequence analysis, and his laboratory at the Washington University School of Medicine is among the world’s leaders in genome analysis. They have sequenced and analyzed billions of bases of DNA from the genomes of bacteria, yeast, roundworms, plants, vertebrates, primates and humans. Dr. Wilson and his colleagues at The Genome Institute sequenced the first animal genome – that of the roundworm Caenorhabditis elegans – and contributed substantially to the sequencing and analysis of the human genome. More recently, Dr. Wilson’s laboratory was the first to sequence the genome of a cancer patient and discover genetic signatures relevant to the pathogenesis of the disease. Building upon this achievement, their current focus is to utilize genome sequencing and analysis technology to discover clues that will facilitate more effective diagnosis and treatment of cancer and other human diseases.

Dr. Wilson is Professor of Genetics, Professor of Molecular Microbiology and Research Member at the Siteman Cancer Center, where he is also a member of the Senior Leadership Committee. Dr. Wilson received his A.B. degree from Miami University in Ohio (Microbiology, 1981), his Ph.D. from the University of Oklahoma (Chemistry and Biochemistry, 1986) and was a Research Fellow in the Division of Biology at the California Institute of Technology.

Publications

title citation publication date
Genome of the house fly, Musca domestica L., a global vector of diseases with adaptations to a septic environment Genome Biology 2014, doi:10.1186/s13059-014-0466-3 2014-10-14
Clonal evolution revealed by whole genome sequencing in a case of primary myelofibrosis transformed to secondary acute myeloid leukemia. Leukemia. 2014 Sep 25. doi: 10.1038/leu.2014.289. [Epub ahead of print] 2014-09-24
The Genomic Landscape of Childhood and Adolescent Melanoma. J Invest Dermatol. 2014 Sep 30. doi: 10.1038/jid.2014.425. [Epub ahead of print] 2014-09-30
Genomic landscape of Ewing sarcoma defines an aggressive subtype with co-association of STAG2 and TP53 mutations. Cancer Discov. 2014 Sep 15. pii: CD-14-0622. [Epub ahead of print] 2014-09-15
A dominant mutation in hexokinase 1 (HK1) causes retinitis pigmentosa. Invest Ophthalmol Vis Sci. 2014 Sep 4. pii: IOVS-14-15419. doi: 10.1167/iovs.14-15419. [Epub ahead of print] 2014-09-04
Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia. N Engl J Med. 2014 Sep 11;371(11):1005-15. doi: 10.1056/NEJMoa1403088. 2014-09-11
Gibbon genome and the fast karyotype evolution of small apes. Nature. 2014 Sep 11;513(7517):195-201. doi: 10.1038/nature13679. 2014-09-11
C11orf95-rela fusions drive oncogenic NF-kb signaling in ependymoma. Neuro Oncol. 2014 Jul;16 Suppl 3:iii16. doi: 10.1093/neuonc/nou206.57. 2014-07-01
SciClone: Inferring Clonal Architecture and Tracking the Spatial and Temporal Patterns of Tumor Evolution. PLoS Comput Biol. 2014 Aug 7;10(8):e1003665. doi: 10.1371/journal.pcbi.1003665. eCollection 2014. 2014-08-07
Comprehensive molecular profiling of lung adenocarcinoma. Nature. 2014 Jul 31;511(7511):543-50. doi: 10.1038/nature13385. Epub 2014 Jul 9. 2014-07-09
The common marmoset genome provides insight into primate biology and evolution. Nat Genet. 2014 Jul 20. doi: 10.1038/ng.3042. [Epub ahead of print] 2014-07-20
Clonal architecture of secondary acute myeloid leukemia defined by single-cell sequencing. PLoS Genet. 2014 Jul 10;10(7):e1004462. doi: 10.1371/journal.pgen.1004462. eCollection 2014. 2014-07-10
Draft Genome Sequence of Acetobacter aceti Strain 1023, a Vinegar Factory Isolate. Genome Announc. 2014 Jun 5;2(3). pii: e00550-14. doi: 10.1128/genomeA.00550-14. 2014-06-05
Finished sequence and assembly of the DUF1220-rich 1q21 region using a haploid human genome. BMC Genomics. 2014 May 20;15:387. doi: 10.1186/1471-2164-15-387. 2014-05-20
Using VarScan 2 for Germline Variant Calling and Somatic Mutation Detection Curr. Protoc. Bioinform. 44:15.4.1?15.4.17. DOI: 10.1002/0471250953.bi1504s44 2013-12-12
The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers. Cancer Cell. 2014 Apr 14;25(4):442-54. doi: 10.1016/j.ccr.2014.02.010. Epub 2014 Mar 20 2014-04-14
Mammalian Y chromosomes retain widely expressed dosage-sensitive regulators. Nature. 2014 Apr 24;508(7497):494-9. doi: 10.1038/nature13206. 2014-04-24
Genome sequence of the tsetse fly (Glossina morsitans): vector of African trypanosomiasis. Science. 2014 Apr 25;344(6182):380-6. doi: 10.1126/science.1249656. 2014-04-25
The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes. Nat Commun. 2014 Apr 8;5:3630. doi: 10.1038/ncomms4630. 2014-04-08
Recurrent somatic structural variations contribute to tumorigenesis in pediatric osteosarcoma. Cell Rep. 2014 Apr 10;7(1):104-12. doi: 10.1016/j.celrep.2014.03.003. Epub 2014 Apr 3. 2014-04-10
The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma. Nat Genet. 2014 May;46(5):444-50. doi: 10.1038/ng.2938. Epub 2014 Apr 6. 2014-05-01
Subtelomeric CTCF and cohesin binding site organization using improved subtelomere assemblies and a novel annotation pipeline. Genome Res. 2014 Mar 27. [Epub ahead of print] 2014-03-27
Functional heterogeneity of genetically defined subclones in acute myeloid leukemia. Cancer Cell. 2014 Mar 17;25(3):379-92. doi: 10.1016/j.ccr.2014.01.031. Epub 2014 Mar 6. 2014-03-17
Ancestry estimation and control of population stratification for sequence-based association studies. Nat Genet. 2014 Apr;46(4):409-15. doi: 10.1038/ng.2924. Epub 2014 Mar 16. 2014-04-01
C11orf95-RELA fusions drive oncogenic NF-kappaB signalling in ependymoma. Nature. 2014 Feb 27;506(7489):451-5. doi: 10.1038/nature13109. Epub 2014 Feb 19. 2014-02-27
RB1 gene inactivation by chromothripsis in human retinoblastoma. Oncotarget. 2014 Jan 11. [Epub ahead of print] 2014-01-11
Exome-Based Mapping and Variant Prioritization for Inherited Mendelian Disorders. Am J Hum Genet. 2014 Feb 19. pii: S0002-9297(14)00054-8. doi: 10.1016/j.ajhg.2014.01.016. [Epub ahead of print] 2014-02-20
Re-sequencing Expands Our Understanding of the Phenotypic Impact of Variants at GWAS Loci. PLoS Genet. 2014 Jan 30;10(1):e1004147. doi: 10.1371/journal.pgen.1004147. eCollection 2014. 2014-01-30
Genome of the human hookworm Necator americanus. Nat Genet. 2014 Jan 19. doi: 10.1038/ng.2875. [Epub ahead of print] 2014-01-19
Integrated analysis of germline and somatic variants in ovarian cancer. Nat Commun. 2014 Jan 22;5:3156. doi: 10.1038/ncomms4156. 2014-01-22
Elephant shark genome provides unique insights into gnathostome evolution. Nature. 2014 Jan 9;505(7482):174-9. doi: 10.1038/nature12826. 2014-01-09
Reconstructing complex regions of genomes using long-read sequencing technology. Genome Res. 2014 Jan 13. [Epub ahead of print] 2014-01-13
Targeting oxidative stress in embryonal rhabdomyosarcoma. Cancer Cell. 2013 Dec 9;24(6):710-24. doi: 10.1016/j.ccr.2013.11.002. 2013-12-09
The DNA double-strand break response is abnormal in myeloblasts from patients with therapy-related acute myeloid leukemia. Leukemia. 2013 Dec 5. doi: 10.1038/leu.2013.368. [Epub ahead of print] 2013-12-05
Genomic landscapes and clonality of de novo AML. N Engl J Med. 2013 Oct 10;369(15):1473. doi: 10.1056/NEJMc1308782. 2013-10-10
No bull: Upholding community standards in public sharing of biological datasets. Proc Natl Acad Sci U S A. 2013 Oct 30. [Epub ahead of print] 2013-10-30
Integrative annotation of variants from 1092 humans: application to cancer genomics. Science. 2013 Oct 4;342(6154):1235587. doi: 10.1126/science.1235587. 2013-10-04
Mutational landscape and significance across 12 major cancer types. Nature. 2013 Oct 17;502(7471):333-9. doi: 10.1038/nature12634. 2013-10-17
The Somatic Genomic Landscape of Glioblastoma. Cell. 2013 Oct 10;155(2):462-477. doi: 10.1016/j.cell.2013.09.034. 2013-10-10
DGIdb: mining the druggable genome. Nat Methods. 2013 Oct 13. doi: 10.1038/nmeth.2689. [Epub ahead of print] 2013-10-13
The next-generation sequencing revolution and its impact on genomics. Cell. 2013 Sep 26;155(1):27-38. doi: 10.1016/j.cell.2013.09.006. 2013-09-26
The Cancer Genome Atlas Pan-Cancer analysis project. Nat Genet. 2013 Sep 26;45(10):1113-20. doi: 10.1038/ng.2764. 2013-09-26
Endocrine-Therapy-Resistant ESR1 Variants Revealed by Genomic Characterization of Breast-Cancer-Derived Xenografts. Cell Rep. 2013 Sep 18. pii: S2211-1247(13)00463-4. doi: 10.1016/j.celrep.2013.08.022. [Epub ahead of print] 2013-09-18
Identification of a rare coding variant in complement 3 associated with age-related macular degeneration. Nat Genet. 2013 Sep 15. doi: 10.1038/ng.2758. [Epub ahead of print] 2013-09-15
BreakTrans: uncovering the genomic architecture of gene fusions. Genome Biol. 2013 Aug 23;14(8):R87. [Epub ahead of print] 2013-08-23
The human genome: genes, pseudogenes, and variation on chromosome 7. Cold Spring Harb Symp Quant Biol. 2003;68:13-22. 2003-01-01
The theory of discovering rare variants via DNA sequencing. BMC Genomics. 2009 Oct 20;10:485. doi: 10.1186/1471-2164-10-485. 2009-10-20
Intestinal transcriptomes of nematodes: comparison of the parasites Ascaris suum and Haemonchus contortus with the free-living Caenorhabditis elegans. PLoS Negl Trop Dis. 2008 Aug 6;2(8):e269. doi: 10.1371/journal.pntd.0000269. 2008-08-01
Oil palm genome sequence reveals divergence of interfertile species in Old and New worlds. Nature. 2013 Jul 24. doi: 10.1038/nature12309. [Epub ahead of print] 2013-07-24
Rates and patterns of great ape retrotransposition. Proc Natl Acad Sci U S A. 2013 Jul 24. [Epub ahead of print] 2013-07-24
A Lover and a Fighter: The Genome Sequence of an Entomopathogenic Nematode Heterorhabditis bacteriophora. PLoS One. 2013 Jul 18;8(7):e69618. doi: 10.1371/journal.pone.0069618. Print 2013. 2013-07-18
Independent specialization of the human and mouse X chromosomes for the male germ line. Nat Genet. 2013 Jul 21. doi: 10.1038/ng.2705. [Epub ahead of print] 2013-07-21
Mutational profiling in the human genome. Cold Spring Harb Symp Quant Biol. 2003;68:23-9. 2003-01-01
A pneumatic device for rapid loading of DNA sequencing gels. Genome Res. 1998 May;8(5):543-8. 1998-05-01
The genome of the nematode Caenorhabditis elegans. Cold Spring Harb Symp Quant Biol. 1993;58:367-76. 1993-01-01
Toward a Complete Human Genome Sequence Genome Res. 1998 Nov;8(11):1097-108. 1998-11-01
Fluorescence chemistries for automated primer-directed DNA sequencing. Electrophoresis. 1992 Aug;13(8):552-9. 1992-08-01
Great ape genetic diversity and population history. Nature. 2013 Jul 3. doi: 10.1038/nature12228. [Epub ahead of print] 2013-07-03
Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia. N Engl J Med. 2013 May 1. [Epub ahead of print] 2013-05-01
Integrated genomic characterization of endometrial carcinoma. Nature. 2013 May 2;497(7447):67-73. doi: 10.1038/nature12113. 2013-05-02
Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas. Nat Genet. 2013 Apr 14. doi: 10.1038/ng.2611. [Epub ahead of print] 2013-04-14
The genome of the platyfish, Xiphophorus maculatus, provides insights into evolutionary adaptation and several complex traits. Nat Genet. 2013 Mar 31. doi: 10.1038/ng.2604. [Epub ahead of print] 2013-03-31
Complete Haplotype Sequence of the Human Immunoglobulin Heavy-Chain Variable, Diversity, and Joining Genes and Characterization of Allelic and Copy-Number Variation. Am J Hum Genet. 2013 Mar 26. pii: S0002-9297(13)00112-2. doi: 10.1016/j.ajhg.2013.03.004. [Epub ahead of print] 2013-03-26
The western painted turtle genome, a model for the evolution of extreme physiological adaptations in a slowly evolving lineage. Genome Biol. 2013 Mar 28;14(3):R28. [Epub ahead of print] 2013-03-18
Retrotransposition of gene transcripts leads to structural variation in mammalian genomes. Genome Biol. 2013 Mar 13;14(3):R22. [Epub ahead of print] 2013-03-13
Clonal diversity of recurrently mutated genes in myelodysplastic syndromes. Leukemia. 2013 Feb 27. doi: 10.1038/leu.2013.58. [Epub ahead of print] 2013-02-27
Sequencing of the sea lamprey (Petromyzon marinus) genome provides insights into vertebrate evolution. Nat Genet. 2013 Feb 24. doi: 10.1038/ng.2568. [Epub ahead of print] 2013-02-24
The characterization of the Phlebotomus papatasi transcriptome. Insect Mol Biol. 2013 Feb 7. doi: 10.1111/imb.12015. [Epub ahead of print] 2013-02-07
The Oxytricha trifallax Macronuclear Genome: A Complex Eukaryotic Genome with 16,000 Tiny Chromosomes. PLoS Biol. 2013 Jan;11(1):e1001473. doi: 10.1371/journal.pbio.1001473. Epub 2013 Jan 29. 2013-01-29
The genomic landscape of hypodiploid acute lymphoblastic leukemia. Nat Genet. 2013 Jan 20. doi: 10.1038/ng.2532. [Epub ahead of print] 2013-01-20
Genomic impact of transient low-dose decitabine treatment on primary AML cells. Blood. 2013 Jan 7. [Epub ahead of print] 2013-01-07
Genomic Pathology of SLE-Associated Copy-Number Variation at the FCGR2C/FCGR3B/FCGR2B Locus. Am J Hum Genet. 2012 Dec 19. pii: S0002-9297(12)00626-X. doi: 10.1016/j.ajhg.2012.11.013. [Epub ahead of print] 2012-12-19
Assessing telomeric DNA content in pediatric cancers using whole-genome sequencing data. Genome Biol. 2012 Dec 11;13(12):R113. [Epub ahead of print] 2012-12-11
Somatic Mutations of PIK3R1 Promote Gliomagenesis PLoS One. 2012;7(11):e49466. doi: 10.1371/journal.pone.0049466. Epub 2012 Nov 14. 2012-11-14
An Inv(16)(p13.3q24.3)-Encoded CBFA2T3-GLIS2 Fusion Protein Defines an Aggressive Subtype of Pediatric Acute Megakaryoblastic Leukemia. Cancer Cell. 2012 Nov 13;22(5):683-97. doi: 10.1016/j.ccr.2012.10.007. 2012-11-13
An integrated map of genetic variation from 1,092 human genomes. Nature. 2012 Nov 1;491(7422):56-65. doi: 10.1038/nature11632. 2012-11-01
Comprehensive molecular portraits of human breast tumours. Nature. 2012 Sep 23. doi: 10.1038/nature11412. [Epub ahead of print] 2012-09-23
Genomic Landscape of Non-Small Cell Lung Cancer in Smokers and Never-Smokers Cell. 2012 Sep 14;150(6):1121-34. doi: 10.1016/j.cell.2012.08.024. 2012-09-14
Evaluation of 16S rDNA-Based Community Profiling for Human Microbiome Research PLoS One. 2012;7(6):e39315. Epub 2012 Jun 13. 2012-06-13
Whole-genome analysis informs breast cancer response to aromatase inhibition. Nature. 2012 Jun 10;486(7403):353-60. doi: 10.1038/nature11143. 2012-06-10
The origin and evolution of mutations in acute myeloid leukemia. Cell. 2012 Jul 20;150(2):264-78. 2012-07-20
The 1000 Genomes Project: data management and community access. Nat Methods. 2012 Apr 27;9(5):459-62. doi: 10.1038/nmeth.1974. 2012-04-27
Comprehensive molecular characterization of human colon and rectal cancer. Nature. 2012 Jul 18;487(7407):330-7. doi: 10.1038/nature11252. 2012-07-18
MuSiC: Identifying mutational significance in cancer genomes. Genome Res. 2012 Jul 3. [Epub ahead of print] 2012-07-03
Landscape of Somatic Retrotransposition in Human Cancers. Science. 2012 Jun 28. [Epub ahead of print] 2012-06-28
Novel mutations target distinct subgroups of medulloblastoma. Nature. 2012 Jun 20. doi: 10.1038/nature11213. [Epub ahead of print] 2012-06-20
A framework for human microbiome research. Nature. 2012 Jun 13;486(7402):215-21. doi: 10.1038/nature11209. 2012-06-13
Structure, function and diversity of the healthy human microbiome. Nature. 2012 Jun 13;486(7402):207-14. doi: 10.1038/nature11234. 2012-06-13
The pediatric cancer genome project. Nat Genet. 2012 May 29;44(6):619-22. doi: 10.1038/ng.2287. 2012-05-29
BreakFusion: Targeted Assembly-based Identification of Gene Fusions in Whole Transcriptome Paired-end Sequencing Data. Bioinformatics. 2012 May 4. [Epub ahead of print] 2012-05-04
Evolution of Human-Specific Neural SRGAP2 Genes by Incomplete Segmental Duplication. Cell. 2012 May 2. [Epub ahead of print] 2012-05-02
A non-human primate system for large-scale genetic studies of complex traits. Hum Mol Genet. 2012 May 3. [Epub ahead of print] 2012-05-03
De novo gene disruptions in children on the autistic spectrum. Neuron. 2012 Apr 26;74(2):285-99. 2012-04-26
Background Mutations in Parental Cells Account for Most of the Genetic Heterogeneity of Induced Pluripotent Stem Cells. Cell Stem Cell. 2012 Apr 26. [Epub ahead of print] 2012-04-26
Resolving the breakpoints of the 17q21.31 microdeletion syndrome with next-generation sequencing. Am J Hum Genet. 2012 Apr 6;90(4):599-613. 2012-04-06
The evolution of African great ape subtelomeric heterochromatin and the fusion of human chromosome 2 Genome Res. 2012 Mar 14. [Epub ahead of print] 2012-03-14
Clonal Architecture of Secondary Acute Myeloid Leukemia. N Engl J Med. 2012 Mar 22;366(12):1090-8. doi: 10.1056/NEJMoa1106968. Epub 2012 Mar 14. 2012-03-14
Association of age at diagnosis and genetic mutations in patients with neuroblastoma. JAMA. 2012 Mar 14;307(10):1062-71. 2012-03-14
Insights into hominid evolution from the gorilla genome sequence. Nature. 2012 Mar 7;483(7388):169-75. doi: 10.1038/nature10842. 2012-03-07
Strict evolutionary conservation followed rapid gene loss on human and rhesus Y chromosomes. Nature. 2012 Feb 22. doi: 10.1038/nature10843. [Epub ahead of print] 2012-02-22
VarScan 2: Somatic mutation and copy number alteration discovery in cancer by exome sequencing. Genome Res. 2012 Feb 2. [Epub ahead of print] 2012-02-12
Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas. Nat Genet. 2012 Jan 29 [Epub ahead of print] 2012-01-29
Chromothripsis and human disease: piecing together the shattering process. Cell. 2012 Jan 20;148(1-2):29-32. 2012-01-20
Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing. Nature. 2012 Jan 11. doi: 10.1038/nature10738. [Epub ahead of print] 2012-01-11
The genetic basis of early T-cell precursor acute lymphoblastic leukaemia. Nature. 2012 Jan 11;481(7380):157-63. doi: 10.1038/nature10725. 2012-01-11
A novel retinoblastoma therapy from genomic and epigenetic analyses. Nature. 2012 Jan 11. doi: 10.1038/nature10733. [Epub ahead of print] 2012-01-11
Massively parallel sequencing approaches for characterization of structural variation. Methods Mol Biol. 2012;838:369-84. 2012-01-06
SomaticSniper: Identification of Somatic Point Mutations in Whole Genome Sequencing Data. Bioinformatics. 2011 Dec 6. [Epub ahead of print] 2011-12-06
Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes. Nat Genet. 2011 Dec 11. doi: 10.1038/ng.1031. [Epub ahead of print] 2011-12-11
The variant call format and VCFtools. Bioinformatics. 2011 Aug 1;27(15):2156-8. Epub 2011 Jun 7. 2011-08-01
The functional spectrum of low-frequency coding variation. Genome Biol. 2011 Sep 14;12(9):R84. [Epub ahead of print] 2011-09-14
A high-resolution map of human evolutionary constraint using 29 mammals. Nature. 2011 Oct 12;478(7370):476-82. doi: 10.1038/nature10530. 2011-10-12
Evolution of symbiotic bacteria in the distal human intestine. PLoS Biol. 2007 Jul;5(7):e156. Epub 2007 Jun 19. 2007-06-19
Analysis of the genome sequence of the flowering plant Arabidopsis thaliana Nature. 2000 Dec 14;408(6814):796-815. 2000-12-14
Variation in genome-wide mutation rates within and between human families. Nat Genet. 2011 Jun 12;43(7):712-714. doi: 10.1038/ng.862. 2011-06-12
Demographic history and rare allele sharing among human populations. Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):11983-11988. Epub 2011 Jul 5. 2011-07-19
Modernizing reference genome assemblies. PLoS Biol. 2011 Jul;9(7):e1001091. Epub 2011 Jul 5. 2011-07-05
The transcriptomes of the cattle parasitic nematode Ostertagia ostartagi. Vet Parasitol. 2009 May 26;162(1-2):89-99. Epub 2009 Feb 27. 2009-05-26
Integrated genomic analyses of ovarian carcinoma Nature. 2011 Jun 29;474(7353):609-15. doi: 10.1038/nature10166. 2011-06-29
Gorilla genome structural variation reveals evolutionary parallelisms with chimpanzee. Genome Res. 2011 Jul 20. [Epub ahead of print] 2011-06-20
CREST maps somatic structural variation in cancer genomes with base-pair resolution. Nat Methods. 2011 Jun 12. doi: 10.1038/nmeth.1628. [Epub ahead of print] 2011-06-12
Identification of a Novel TP53 Cancer Susceptibility Mutation Through Whole-Genome Sequencing of a Patient With Therapy-Related AML JAMA. 2011 Apr 20;305(15):1568-1576. 2011-04-20
Use of Whole-Genome Sequencing to Diagnose a Cryptic Fusion Oncogene JAMA. 2011 Apr 20;305(15):1577-84. 2011-04-20
PathScan: A Tool for Discerning Mutational Significance in Groups of Putative Cancer Genes. Bioinformatics. 2011 Jun 15;27(12):1595-602. Epub 2011 Apr 14. 2011-04-14
A vertebrate case study of the quality of assemblies derived from next-generation sequences. Genome Biol. 2011 Mar 31;12(3):R31. [Epub ahead of print] 2011-03-31
Sequencing a mouse acute promyelocytic leukemia genome reveals genetic events relevant for disease progression. J Clin Invest. 2011 Mar 23. pii: 45284. doi: 10.1172/JCI45284. [Epub ahead of print] 2011-03-23
Recurrent DNMT3A mutations in patients with myelodysplastic syndromes. Leukemia. 2011 Jul;25(7):1153-8. doi: 10.1038/leu.2011.44. Epub 2011 Mar 18. 2011-03-18
The draft genome of the parasitic nematode Trichinella spiralis Nat Genet. 2011 Mar;43(3):228-35. Epub 2011 Feb 20. 2011-02-20
Mapping copy number variation by population-scale genome sequencing. Nature. 2011 Feb 3;470(7332):59-65. 2011-02-03
Comparative and demographic analysis of orang-utan genomes Nature. 2011 Jan 27;469(7331):529-33. 2011-01-27
A large and complex structural polymorphism at 16p12.1 underlies microdeletion disease risk. Nat Genet. 2010 Sep;42(9):745-50. Epub 2010 Aug 22. 2010-09-01
Complete characterization of the microRNAome in a patient with acute myeloid leukemia. Blood. 2010 Dec 9;116(24):5316-26. Epub 2010 Sep 28. 2010-12-09
Novel venom gene discovery in the platypus. Genome Biol. 2010;11(9):R95. Epub 2010 Sep 29. 2010-09-29
Diversity of human copy number variation and multicopy genes. Science. 2010 Oct 29;330(6004):641-6. 2010-10-29
Challenges of sequencing human genomes. Brief Bioinform. 2010 Sep;11(5):484-98. Epub 2010 Jun 2. 2010-09-11
A human genome structural variation sequencing resource reveals insights into mutational mechanisms. Cell. 2010 Nov 24;143(5):837-47. 2010-11-24
DNMT3A Mutations in Acute Myeloid Leukemia N Engl J Med. 2010 Nov 10. 2010-11-10
A map of human genome variation from population-scale sequencing Nature. 2010 Oct 28;467(7319):1050-1. 2010-10-28
Convergent evolution of chicken Z and human X chromosomes by expansion and gene acquisition. Nature. 2010 Jul 11. [Epub ahead of print] 2010-07-11
The genome of the Western clawed frog Xenopus tropicalis. Science. 2010 Apr 30;328(5978):633-6. 2010-04-30
Characterization of missing human genome sequences and copy-number polymorphic insertions. Nat Methods. 2010 May;7(5):365-71. 2010-05-01
Characterizing Ancylostoma caninum transcriptome and exploring nematode parasitic adaptation. BMC Genomics. 2010 May 14;11:307. 2010-05-14
International network of cancer genome projects. Nature. 2010 Apr 15;464(7291):993-8. 2010-04-15
Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma. Cancer Cell. 2010 May 18;17(5):510-22. Epub 2010 Apr 15. 2010-05-18
Comparative genomics based on massive parallel transcriptome sequencing reveals patterns of substitution and selection across 10 bird species. Mol Ecol. 2010 Mar;19 Suppl 1:266-76. 2010-03-19
Genome sequence of Cronobacter sakazakii BAA-894 and comparative genomic hybridization analysis with other Cronobacter species. PLoS One. 2010 Mar 8;5(3):e9556. 2010-03-08
A Catalog of Reference Genomes from the Human Microbiome. Science. 2010 May 21;328(5981):994-999. 2010-05-21
Next-generation sequencing of cancer genomes: back to the future. Per Med. 2009 Nov 1;6(6):653. 2009-11-01
The genome of a songbird. Nature. 2010 Apr 1;464(7289):757-62. 2010-04-01
Genome remodelling in a basal-like breast cancer metastasis and xenograft. Nature. 2010 Apr 15;464(7291):989-90. 2010-04-15
Chimpanzee and human Y chromosomes are remarkably divergent in structure and gene content. Nature. 2010 Jan 28;463(7280):536-9. Epub 2010 Jan 13. 2010-01-13
Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell, Volume 17, Issue 1, 98-110, 19 January 2010. 2010-01-19
CMDS: a population-based method for identifying recurrent DNA copy number aberrations in cancer from high-resolution data. Bioinformatics. 2009 Dec 23. [Epub ahead of print] 2009-12-23
Detailed analysis of a contiguous 22-Mb region of the maize genome. PLoS Genet. 2009 Nov;5(11):e1000728. Epub 2009 Nov 20. 2009-11-20
The physical and genetic framework of the maize B73 genome. PLoS Genet. 2009 Nov;5(11):e1000715. Epub 2009 Nov 20. 2009-11-20
The B73 maize genome: complexity, diversity, and dynamics. Science. 2009 Nov 20;326(5956):1112-5. 2009-11-20
Statistical aspects of discerning indel-type structural variation via DNA sequence alignment. BMC Genomics. 2009 Oct 20;10(1):485. [Epub ahead of print] 2009-10-20
BreakDancer: an algorithm for high-resolution mapping of genomic structural variation. Nat Methods. 2009 Sep;6(9):677-81. Epub 2009 Aug 9. 2009-09-06
Acquired copy number alterations in adult acute myeloid leukemia genomes. Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12950-5. Epub 2009 Jul 27. 2009-08-04
Recurring mutations found by sequencing an acute myeloid leukemia genome. N Engl J Med. 2009 Sep 10;361(11):1058-66. Epub 2009 Aug 5. 2009-09-10
Cancer genome sequencing: a review. Hum Mol Genet. 2009 Oct 15;18(R2):R163-8. 2009-10-04
Transcriptomic analysis of the entomopathogenic nematode, Heterorhabditis bacteriophora TTO1. BMC Genomics. 2009 Apr 30;10(1):205. 2009-04-30
Characterizing a model human gut microbiota composed of members of its two dominant bacterial phyla. Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5859-64. Epub 2009 Mar 24. 2009-03-24
Molecular determinants archetypical to the phylum Nematoda. BMC Genomics. 2009 Mar 18;10:114. 2009-03-18
A burst of segmental duplications in the genome of the African great ape ancestor. Nature. 2009 Feb 12;457(7231):877-81. 2009-02-12
VarScan: Variant detection in massively parallel sequencing of individual and pooled samples. Bioinformatics. 2009 Sep 1;25(17):2283-5. Epub 2009 Jun 19. 2009-06-19
Sequencing human-gibbon breakpoints of synteny reveals mosaic new insertions at rearrangement sites. Genome Res. 2008 Nov 24. [Epub ahead of print] 2008-11-24
DNA sequencing of a cytogenetically normal acute myeloid leukaemia (AML) genome. Nature. 2008 Nov 6;456(7218):66-72. 2008-11-06
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