Vincent Magrini, Ph.D.
Research Accomplishments & Interests
Dr. Vincent Magrini began his Washington University career as a Research Associate in the Department of Molecular Microbiology in 1999. While in this position, he researched the molecular mechanism associated with the mycelial to yeast transition in the human fungal pathogen, Histoplasma capsulatum, and how this dimorphic switch is associated with Histoplasma pathogenesis. Dr. Magrini joined The Genome Institute in 2002, working in Dr. Elaine Mardis' Technology Development Group. In 2004, he became a Senior Scientist, a Research Instructor in 2005, and Research Assistant Professor in 2008. His group focuses on optimizing molecular applications associated with next-generation sequencing platforms. As a trained microbiologist, he has an active interest in genomic and genetic analyses of bacteria, fungi and viruses with a particular emphasis on infectious diseases and evolutionary studies.
Dr. Magrini's work also includes involvement with the Human Microbiome Project (HMP). This project aims to study the collection of microorganisms residing on and in the human body (called the human microbiome) and understand their impacts and interactions with respect to normal health and potential pathogenic states. He is an active participant in many of the project working groups, and has co-chaired the metagenomics working group. He is a member of the Microbiome Metatgenomic Research Unit (MMRU), formed at The Genome Institute for the purpose of directing microbiome related projects.
Other Biographical information
Dr. Magrini received a B. S. (Bacteriology, 1993) from the University of Idaho. His Ph.D. dissertation (Microbiology, 1999) examined temperate phage mechanisms of site-specific integration under the guidance of Dr. Philip Youderian, while also attending University of Idaho.
Selected Publications
Iossifov I, Ronemus M, Levy D, Wang Z, Hakker I, Rosenbaum J, Yamrom B, Lee…
De novo gene disruptions in children on the autistic spectrum.
Neuron. 2012 Apr 26;74(2):285-99. PubMed | View Abstract
Walter MJ, Shen D, Ding L, Shao J, Koboldt DC, Chen K, Larson DE, McLellan…
Clonal Architecture of Secondary Acute Myeloid Leukemia.
N Engl J Med. 2012 Mar 14. [Epub ahead of print] PubMed | View Abstract
Matsushita H, Vesely MD, Koboldt DC, Rickert CG, Uppaluri R, Magrini VJ, Arthur CD, White…
Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting.
Nature. 2012 Feb 8 [Epub ahead of print]. PubMed | View Abstract
Ding L, Ley TJ, Larson DE, Miller CA, Koboldt DC, Welch JS, Ritchey JK, Young…
Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing.
Nature. 2012 Jan 11. doi: 10.1038/nature10738. [Epub ahead of print] PubMed | View Abstract
Swart EC, Nowacki M, Shum J, Stiles H, Higgins BP, Doak TG, Schotanus K, Magrini…
The Oxytricha trifallax mitochondrial genome.
Genome Biol Evol. 2011 Dec 16. [Epub ahead of print] PubMed | View Abstract
The Cancer Genome Atlas Research Network
Integrated genomic analyses of ovarian carcinoma
Nature. 2011 Jun 29;474(7353):609-15. doi: 10.1038/nature10166. PubMed | View Abstract
Jung S, Swart EC, Minx PJ, Magrini V, Mardis ER, Landweber LF, Eddy SR.
Exploiting Oxytricha trifallax nanochromosomes to screen for non-coding RNA genes.
Nucleic Acids Res. 2011 Jun 28. [Epub ahead of print] PubMed | View Abstract
Duncavage EJ, Magrini V, Becker N, Armstrong JR, Demeter RT, Wylie T, Abel HJ, Pfeifer…
Hybrid capture and next-generation sequencing identify viral integration sites from formalin-fixed, paraffin-embedded tissue.
J Mol Diagn. 2011 May;13(3):325-33. PubMed | View Abstract
Forgetta V, Oughton MT, Marquis P, Brukner I, Blanchette R, Haub K, Magrini V, Mardis…
Fourteen-Genome Comparison Identifies DNA Markers for Severe Disease-Associated Strains of Clostridium difficile.
J Clin Microbiol. 2011 Jun;49(6):2230-8. Epub 2011 Apr 20. PubMed | View Abstract
Muthappan V, Lee AY, Lamprecht TL, Akileswaran L, Dintzis SM, Lee C, Magrini V, Mardis…
Biome representational in silico karyotyping.
Genome Res. 2011 Apr;21(4):626-33. Epub 2011 Feb 10. PubMed | View Abstract
Locke DP, Hillier LW, Warren WC, Worley KC, Nazareth LV, Muzny DM, Yang SP, Wang…
Comparative and demographic analysis of orang-utan genomes
Nature. 2011 Jan 27;469(7331):529-33. PubMed | View Abstract
Ramsingh G, Koboldt DC, Trissal M, Chiappinelli KB, Wylie T, Koul S, Chang LW, Nagarajan…
Complete characterization of the microRNAome in a patient with acute myeloid leukemia.
Blood. 2010 Dec 9;116(24):5316-26. Epub 2010 Sep 28. PubMed | View Abstract
Ley TJ, Ding L, Walter MJ, McLellan MD, Lamprecht T, Larson DE, Kandoth C, Payton…
DNMT3A Mutations in Acute Myeloid Leukemia
N Engl J Med. 2010 Nov 10. PubMed | View Abstract
Fehniger TA, Wylie T, Germino E, Leong JW, Magrini VJ, Koul S, Keppel CR, Schneider…
Next-generation sequencing identifies the natural killer cell microRNA transcriptome.
Genome Res. 2010 Nov;20(11):1590-604. Epub 2010 Oct 8. PubMed | View Abstract
Abel HJ, Duncavage EJ, Becker N, Armstrong JR, Magrini VJ, Pfeifer JD.
SLOPE: a quick and accurate method for locating non-SNP structural variation from targeted next-generation sequence data.
Bioinformatics. 2010 Nov 1;26(21):2684-8. Epub 2010 Sep 27. PubMed | View Abstract
