Dr. Christopher Maher is an Assistant Professor of Medicine in the Medical Oncology section of Washington University's Department of Medicine. He is also an Assistant Director at The Genome Institute. His interests include computational biology and bioinformatics as they apply to cancer genomics. He is working to integrate the analysis of high-throughput genomic technologies into the development of novel diagnostic, prognostic and therapeutic strategies in cancer.
Dr. Maher's main research focus is on the development of novel computational tools and approaches to help analyze and interpret data from high-throughput genomic technologies. He participated in the development of the ChimeraScan tool that can detect gene fusions within next-generation transcriptome sequencing data. By applying this tool to prostate cancer transcriptome data, Dr. Maher and his colleagues discovered a clinically relevant class of gene fusions that respond to currently available FDA approved drugs.
Dr. Maher continues to work on the development and application of more integrated analyses of cancer genomics data to help identify new mutations and discover clinically relevant cancer targets and pathways.
Dr. Maher completed his B.S. degree at Cornell University and his M.S./Ph.D. degrees at Cold Spring Harbor Laboratory and Stony Brook University in New York. Most recently he was a Research Investigator at the University of Michigan.
Further information about Dr. Maher can be found through the Washington University Divisions of Hematology & Oncology.
Publication listings available here.
Maher CA, Wilson RK.
Chromothripsis and human disease: piecing together the shattering process.
Cell. 2012 Jan 20;148(1-2):29-32. PubMed | View Abstract