Makedonka Mitreva, Ph.D.
Makedonka Mitreva, Ph.D.
Assistant Director, Integrated Genomics, Nematode.Net
Email Makedonka Mitreva
Research Accomplishments & Interests
Dr. Makedonka Mitreva joined Washington University School of Medicine in 2002 and currently serves as Assistant Director of The Genome Institute and Research Assistant Professor of Genetics. Dr. Mitreva is applying integrated approaches to the exploration of genome data, prompting a deeper understanding of an organism at the molecular level. She supervises the Integrated Genomics group that provides a data management platform and performs comprehensive analysis of transcriptomes, genomes and metagenomes in a comparative context.
Dr. Mitreva has led the world's largest effort to sequence transcriptomes of human, animal and plant parasitic nematodes, and currently directs the sequencing of the genomes of numerous parasitic nematodes and drug resistant strains. This work is accelerating both basic research as well as the development of effective diagnostics, vaccines and new drugs.
Dr. Mitreva and her group make their data available on www.nematode.net, a publicly shared resource dedicated to the study of parasitic nematodes. Coupled with statistical tools, this data provides the scientific community with a solid platform for comparative metabolomics and functional genomics in nematodes. She focuses particularly on metazoan protein evolution and other molecular characteristics that may serve as potential drug targets.
Dr. Mitreva is also involved in exploring the human microbiome (the collection of microbes that colonize the human body) in a functional context. She makes use of computational tools to enable structural and functional characterization of these microbial communities. This comparative metagenomics work will lead to a deeper understanding of how these organisms influence human physiology, nutrition, immunity and development.
Other Biographical Information
Dr. Mitreva received B.S. and M.S. degrees from Ss. Cyril and Methodius University in Skopje, Macedonia and a Ph.D. from the foremost European center for nematology - Wageningen University and Research Centre (WURC) in The Netherlands.
Selected Publications
Rao RU, Huang Y, Abubucker S, Heinz M, Crosby SD, Mitreva M, Weil GJ.
Effects of Doxycycline on gene expression in Wolbachia and Brugia malayi adult female worms in vivo.
J Biomed Sci. 2012 Feb 9;19(1):21. [Epub ahead of print] PubMed | View Abstract
Mitreva M.
The genome of a blood fluke associated with human cancer.
Nat Genet. 2012 Jan 27;44(2):116-8. doi: 10.1038/ng.1082. PubMed | View Abstract
Martin J, Abubucker S, Heizer E, Taylor CM, Mitreva M.
Nematode.net update 2011: addition of data sets and tools featuring next-generation sequencing data.
Nucleic Acids Res. 2011 Dec 1. [Epub ahead of print] PubMed | View Abstract
Soblik H, Younis AE, Mitreva M, Renard BY, Kirchner M, Geisinger F, Steen H, Brattig…
Life cycle stage-resolved proteomic analysis of the excretome/secretome from Strongyloides ratti: Identification of stage-specific protease.
Mol Cell Proteomics. 2011 Oct 16. [Epub ahead of print]. PubMed | View Abstract
Younis AE, Geisinger F, Ajonina-Ekoti I, Soblik H, Steen H, Mitreva M, Erttmann KD, Perbandt…
Stage-specific excretory-secretory small heat shock proteins from the parasitic nematode Strongyloides ratti--putative links to host's intestinal mucosal defense system.
FEBS J. 2011 Sep;278(18):3319-36. doi: 10.1111/j.1742-4658.2011.08248.x. Epub 2011 Aug 24. PubMed | View Abstract
Abubucker S, Martin J, Taylor CM, Mitreva M.
HelmCoP: an online resource for helminth functional genomics and drug and vaccine targets prioritiza
PLoS One. 2011;6(7):e21832. Epub 2011 Jul 8. PubMed | View Abstract
Wang J, Czech B, Crunk A, Wallace A, Mitreva M, Hannon GJ, Davis RE.
Deep small RNA sequencing from the nematode Ascaris reveals conservation, functional diversification, and novel developmental profiles.
Genome Res. 2011 Jun 17. [Epub ahead of print] PubMed | View Abstract
Dalzell JJ, McVeigh P, Warnock ND, Mitreva M, Bird DM, Abad P, Fleming CC, Day…
RNAi Effector Diversity in Nematodes.
PLoS Negl Trop Dis. 2011 Jun;5(6):e1176. Epub 2011 Jun 7. PubMed | View Abstract
Taylor CM, Fischer K, Abubucker S, Wang Z, Martin J, Jiang D, Magliano M, Rosso…
Targeting protein-protein interactions for parasite control.
PLoS One. 2011 Apr 27;6(4):e18381. PubMed | View Abstract
Zhang Z, Wang Y, Wang S, Liu J, Warren W, Mitreva M, Walter RB.
Transcriptome Analysis of Female and Male Xiphophorus maculatus Jp 163 A.
PLoS One. 2011 Apr 5;6(4):e18379. PubMed | View Abstract
Ye L, Hillier LW, Minx P, Thane N, Locke D, Martin JC, Chen L, Mitreva…
A vertebrate case study of the quality of assemblies derived from next-generation sequences.
Genome Biol. 2011 Mar 31;12(3):R31. [Epub ahead of print] PubMed | View Abstract
Mitreva M, Jasmer DP, Zarlenga DS, Wang Z, Abubucker S, Martin J, Taylor CM, Yin…
The draft genome of the parasitic nematode Trichinella spiralis
Nature Genetics 2011 doi:10.1038/ng.769 PubMed | View Abstract
Locke DP, Hillier LW, Warren WC, Worley KC, Nazareth LV, Muzny DM, Yang SP, Wang…
Comparative and demographic analysis of orang-utan genomes
Nature. 2011 Jan 27;469(7331):529-33. PubMed | View Abstract
Li BW, Rush AC, Jiang DJ, Mitreva M, Abubucker S, Weil GJ.
Gender-associated genes in filarial nematodes are important for reproduction and potential intervention targets.
PLoS Negl Trop Dis. 2011 Jan 25;5(1):e947. PubMed | View Abstract
Cantacessi C, Gasser RB, Strube C, Schnieder T, Jex AR, Hall RS, Campbell BE, Young…
Deep insights into Dictyocaulus viviparus transcriptomes provides unique prospects for new drug targets and disease intervention.
Biotechnol Adv. 2010 Dec 22. PubMed | View Abstract
