Wes Warren, Ph.D.
Research Accomplishments & Interests
Dr. Wesley Warren joined The Genome Institute in 2001 where he currently serves as Assistant Director of Genomics. Previously Dr. Warren served as Director of the Microarray Core Facility and Director of Mapping at The Genome Institute supervising construction of whole genome physical maps, sequence gap closure in select species and the study of human genome structural variation.
Dr. Warren's research interests focus on the use of whole genome analysis methods to dissect the underlying molecular signatures linked to biological observations in various species of vertebrates. Dr. Warren's research involves the use of whole genome comparative methods to examine gene loss and gain events as a means to better understand human biology. The identification of these gene aberrations in evolutionary time promises to engender new thoughts on the molecular workings of observed phenotypes. Dr. Warren has played a lead role in the analysis of the chicken, platypus and zebra finch genomes and is an integral team member in the analysis of the macaque, orangutan, tarsier and marmoset genomes. He also co-leads a consortium tasked with the sequencing and characterization of the Y chromosomes of several mammals and the bird Z and W chromosomes In addition to whole genome analysis research, Dr. Warren leads a de novo genome assembly group that is seeking better ways to construct assemblies from next-generation sequencing platforms.
Other Biographical Information
Dr. Warren received his B.S. degree from Oklahoma State University (animal sciences, 1984), M.S. degree from Clemson University (reproductive physiology, 1987) and Ph.D. from the University of Missouri (molecular endocrinology, 1990). A post-doctoral fellowship was completed at G.D. Searle Pharmaceutical before joining Monsanto Company, where he held several leadership roles including group manager of genome initiatives. Prior to joining Washington University, he was Senior Director of Operations at Incyte Genomics.
Selected Publications
Jasinska AJ, Lin MK, Service S, Choi OW, Deyoung J, Grujic O, Kong SY, Jung…
A non-human primate system for large-scale genetic studies of complex traits.
Hum Mol Genet. 2012 May 3. [Epub ahead of print] PubMed | View Abstract
Scally A, Dutheil JY, Hillier LW, Jordan GE, Goodhead I, Herrero J, Hobolth A, Lappalainen…
Insights into hominid evolution from the gorilla genome sequence.
Nature. 2012 Mar 7;483(7388):169-75. doi: 10.1038/nature10842. PubMed | View Abstract
Hughes JF, Skaletsky H, Brown LG, Pyntikova T, Graves T, Fulton RS, Dugan S, Ding…
Strict evolutionary conservation followed rapid gene loss on human and rhesus Y chromosomes.
Nature. 2012 Feb 22. doi: 10.1038/nature10843. [Epub ahead of print] PubMed | View Abstract
Yao G, Ye L, Gao H, Minx P, Warren WC, Weinstock GM.
Graph accordance of next-generation sequence assemblies.
Bioinformatics. 2011 Oct 23. [Epub ahead of print] PubMed | View Abstract
Lindblad-Toh K, Garber M, Zuk O, Lin MF, Parker BJ, Washietl S, Kheradpour P, Ernst…
A high-resolution map of human evolutionary constraint using 29 mammals.
Nature. 2011 Oct 12;478(7370):476-82. doi: 10.1038/nature10530. PubMed | View Abstract
Zhang Z, Wang Y, Wang S, Liu J, Warren W, Mitreva M, Walter RB.
Transcriptome Analysis of Female and Male Xiphophorus maculatus Jp 163 A.
PLoS One. 2011 Apr 5;6(4):e18379. PubMed | View Abstract
Shen Y, Catchen J, Garcia T, Amores A, Beldroth I, Wagner JR, Zhang Z, Postlethwait…
Identification of transcriptome SNPs between Xiphophorus lines and species for assessing allele specific gene expression within F(1) interspecies hybrids.
Comp Biochem Physiol C Toxicol Pharmacol. 2011 Apr 3. [Epub ahead of print] PubMed | View Abstract
Ye L, Hillier LW, Minx P, Thane N, Locke D, Martin JC, Chen L, Mitreva…
A vertebrate case study of the quality of assemblies derived from next-generation sequences.
Genome Biol. 2011 Mar 31;12(3):R31. [Epub ahead of print] PubMed | View Abstract
Mitreva M, Jasmer DP, Zarlenga DS, Wang Z, Abubucker S, Martin J, Taylor CM, Yin…
The draft genome of the parasitic nematode Trichinella spiralis
Nature Genetics 2011 doi:10.1038/ng.769 PubMed | View Abstract
Suen G, Teiling C, Li L, Holt C, Abouheif E, Bornberg-Bauer E, Bouffard P, Caldera…
The Genome Sequence of the Leaf-Cutter Ant Atta cephalotes Reveals Insights into Its Obligate Symbiotic Lifestyle
PLoS Genet. 2011 Feb 10;7(2):e1002007. PubMed | View Abstract
Locke DP, Hillier LW, Warren WC, Worley KC, Nazareth LV, Muzny DM, Yang SP, Wang…
Comparative and demographic analysis of orang-utan genomes
Nature. 2011 Jan 27;469(7331):529-33. PubMed | View Abstract
Whittington CM, Papenfuss AT, Locke DP, Mardis ER, Wilson RK, Abubucker S, Mitreva M, Wong…
Novel venom gene discovery in the platypus.
Genome Biol. 2010;11(9):R95. Epub 2010 Sep 29. PubMed | View Abstract
Bellott DW, Skaletsky H, Pyntikova T, Mardis ER, Graves T, Kremitzki C, Brown LG, Rozen…
Convergent evolution of chicken Z and human X chromosomes by expansion and gene acquisition.
Nature. 2010 Jul 11. [Epub ahead of print] PubMed | View Abstract
The Human Microbiome Jumpstart Reference Strains Consortium, Nelson KE, Weinstock GM, Highlander SK, Worley KC,…
A Catalog of Reference Genomes from the Human Microbiome.
Science. 2010 May 21;328(5981):994-999. PubMed | View Abstract
Hellsten U, Harland RM, Gilchrist MJ, Hendrix D, Jurka J, Kapitonov V, Ovcharenko I, Putnam…
The genome of the Western clawed frog Xenopus tropicalis.
Science. 2010 Apr 30;328(5978):633-6. PubMed | View Abstract
