George Weinstock, Ph.D.
George Weinstock, Ph.D.
Associate Director
Mailing Address
Email George Weinstock
Phone: +1-314-286-1879
Assistant: Pamela Nangle
Email Pamela Nangle
Phone: +1-314-286-1898
Dr. Weinstock applies high-throughput DNA sequencing, genome-wide analysis, bioinformatics, and other genetic methods to the study of human, model organisms and microbial genomes. His goal is to employ genetic and genomic thinking to important problems in biology. He led one of the first bacterial genome projects, sequencing Treponema pallidum, the causative agent of syphilis. He is now a leader of the Human Microbiome Project, studying the collection of microbes that colonize the human body. The goal of this work is to analyze the genomes of these organisms, characterize the communities they form, and measure how communities change in different health and disease states. He was one of the leaders of the Human Genome Project and also the first personal genome project, sequencing Dr. James Watson’s genome using next-generation sequencing technology. He is now leading projects using next-generation sequencing to discover mutations causing human disease.
Currently Professor of Genetics and Professor of Molecular Microbiology at Washington University, Dr. Weinstock was previously Co-Director of the Human Genome Sequencing Center at Baylor College of Medicine in Houston, TX and Professor of Molecular and Human Genetics there. Dr. Weinstock received his B.S. degree from the University of Michigan (Biophysics, 1970) and his Ph.D. from the Massachusetts Institute of Technology (Microbiology, 1977).
Selected Publications
Jasinska AJ, Lin MK, Service S, Choi OW, Deyoung J, Grujic O, Kong SY, Jung…
A non-human primate system for large-scale genetic studies of complex traits.
Hum Mol Genet. 2012 May 3. [Epub ahead of print] PubMed | View Abstract
Smajs D, Norris SJ, Weinstock GM.
Genetic diversity in Treponema pallidum: Implications for pathogenesis, evolution and molecular diagnostics of syphilis and yaws.
Infect Genet Evol. 2011 Dec 15. [Epub ahead of print] PubMed | View Abstract
Holtz LR, Wylie KM, Sodergren E, Jiang Y, Franz CJ, Weinstock GM, Storch GA, Wang…
Astrovirus MLB2 Viremia in Febrile Child.
Emerg Infect Dis. 2011 Nov;17(11):2050-2. PubMed | View Abstract
Yao G, Ye L, Gao H, Minx P, Warren WC, Weinstock GM.
Graph accordance of next-generation sequence assemblies.
Bioinformatics. 2011 Oct 23. [Epub ahead of print] PubMed | View Abstract
Lindblad-Toh K, Garber M, Zuk O, Lin MF, Parker BJ, Washietl S, Kheradpour P, Ernst…
A high-resolution map of human evolutionary constraint using 29 mammals.
Nature. 2011 Oct 12;478(7370):476-82. doi: 10.1038/nature10530. PubMed | View Abstract
Monier A, Welsh RM, Gentemann C, Weinstock G, Sodergren E, Armbrust EV, Eisen JA, Worden…
Phosphate transporters in marine phytoplankton and their viruses: cross-domain commonalities in viral-host gene exchanges.
Environ Microbiol. 2011 Sep 14. doi: 10.1111/j.1462-2920.2011.02576.x. [Epub ahead of print] PubMed | View Abstract
Marth GT, Yu F, Indap AR, Garimella K, Gravel S, Leong WF, Tyler-Smith C, Bainbridge…
The functional spectrum of low-frequency coding variation.
Genome Biol. 2011 Sep 14;12(9):R84. [Epub ahead of print] PubMed | View Abstract
Arias CA, Panesso D, McGrath DM, Qin X, Mojica MF, Miller C, Diaz L, Tran…
Genetic Basis for In Vivo Daptomycin Resistance in Enterococci
N Engl J Med. 2011 Sep 8;365(10):892-900. PubMed | View Abstract
Renfree MB, Papenfuss AT, Deakin JE, Lindsay J, Heider T, Belov K, Rens W, Waters…
Genome sequence of an Australian kangaroo, Macropus eugenii, provides insight into the evolution of mammalian reproduction and development.
Genome Biol. 2011 Aug 29;12(8):R81. [Epub ahead of print] PubMed | View Abstract
Danecek P, Auton A, Abecasis G, Albers CA, Banks E, DePristo MA, Handsaker RE, Lunter…
The variant call format and VCFtools.
Bioinformatics. 2011 Aug 1;27(15):2156-8. Epub 2011 Jun 7. PubMed | View Abstract
Gravel S, Henn BM, Gutenkunst RN, Indap AR, Marth GT, Clark AG, Yu F, Gibbs…
Demographic history and rare allele sharing among human populations.
Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):11983-11988. Epub 2011 Jul 5. PubMed | View Abstract
Church DM, Schneider VA, Graves T, Auger K, Cunningham F, Bouk N, Chen HC, Agarwala…
Modernizing reference genome assemblies.
PLoS Biol. 2011 Jul;9(7):e1001091. Epub 2011 Jul 5. PubMed | View Abstract
The Cancer Genome Atlas Research Network
Integrated genomic analyses of ovarian carcinoma
Nature. 2011 Jun 29;474(7353):609-15. doi: 10.1038/nature10166. PubMed | View Abstract
The 1000 Genomes Project, Conrad DF, Keebler JE, Depristo MA, Lindsay SJ, Zhang Y, Casals…
Variation in genome-wide mutation rates within and between human families.
Nat Genet. 2011 Jun 12;43(7):712-714. doi: 10.1038/ng.862. PubMed | View Abstract
Bowne SJ, Humphries MM, Sullivan LS, Kenna PF, Tam LC, Kiang AS, Campbell M, Weinstock…
A dominant mutation in RPE65 identified by whole-exome sequencing causes retinitis pigmentosa with choroidal involvement.
Eur J Hum Genet. 2011 Jun 8. doi: 10.1038/ejhg.2011.86. [Epub ahead of print] PubMed | View Abstract
