Michael Wendl, Ph.D.
Research Interests
Dr. Michael Wendl is broadly interested in the development and application of mathematical theory and computational methods for pressing problems in the biomedical and engineering sciences. He has participated in many of the "big biology" efforts of our time, including the Human Genome Project, and is lately part of a research group at The Genome Institute focusing on cancer genomics. He is a leading expert in the industrial engineering aspects of DNA sequencing and a proponent of mathematical and scientific literacy for the general public. Wendl received BS (1989), MS (1990), and Doctoral (1994) degrees, all from Washington University, after which he joined The Genome Institute.
Selected Publications
Young MA, Larson DE, Sun CW, George DR, Ding L, Miller CA, Lin L, Pawlik…
Background Mutations in Parental Cells Account for Most of the Genetic Heterogeneity of Induced Pluripotent Stem Cells.
Cell Stem Cell. 2012 Apr 26. [Epub ahead of print] PubMed | View Abstract
Matsushita H, Vesely MD, Koboldt DC, Rickert CG, Uppaluri R, Magrini VJ, Arthur CD, White…
Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting.
Nature. 2012 Feb 8 [Epub ahead of print]. PubMed | View Abstract
Ding L, Ley TJ, Larson DE, Miller CA, Koboldt DC, Welch JS, Ritchey JK, Young…
Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing.
Nature. 2012 Jan 11. doi: 10.1038/nature10738. [Epub ahead of print] PubMed | View Abstract
Marth GT, Yu F, Indap AR, Garimella K, Gravel S, Leong WF, Tyler-Smith C, Bainbridge…
The functional spectrum of low-frequency coding variation.
Genome Biol. 2011 Sep 14;12(9):R84. [Epub ahead of print] PubMed | View Abstract
Danecek P, Auton A, Abecasis G, Albers CA, Banks E, DePristo MA, Handsaker RE, Lunter…
The variant call format and VCFtools.
Bioinformatics. 2011 Aug 1;27(15):2156-8. Epub 2011 Jun 7. PubMed | View Abstract
Gravel S, Henn BM, Gutenkunst RN, Indap AR, Marth GT, Clark AG, Yu F, Gibbs…
Demographic history and rare allele sharing among human populations.
Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):11983-11988. Epub 2011 Jul 5. PubMed | View Abstract
The Cancer Genome Atlas Research Network
Integrated genomic analyses of ovarian carcinoma
Nature. 2011 Jun 29;474(7353):609-15. doi: 10.1038/nature10166. PubMed | View Abstract
The 1000 Genomes Project, Conrad DF, Keebler JE, Depristo MA, Lindsay SJ, Zhang Y, Casals…
Variation in genome-wide mutation rates within and between human families.
Nat Genet. 2011 Jun 12;43(7):712-714. doi: 10.1038/ng.862. PubMed | View Abstract
Wendl MC, Wallis JW, Lin L, Kandoth C, Mardis ER, Wilson RK, Ding L.
PathScan: A Tool for Discerning Mutational Significance in Groups of Putative Cancer Genes.
Bioinformatics. 2011 Jun 15;27(12):1595-602. Epub 2011 Apr 14. PubMed | View Abstract
The 1000 Genomes Project Consortium
A map of human genome variation from population-scale sequencing
Nature. 2010 Oct 28;467(7319):1050-1. PubMed | View Abstract
Ding L, Wendl MC, Koboldt DC, Mardis ER.
Analysis of next-generation genomic data in cancer: accomplishments and challenges.
Hum Mol Genet. 2010 Oct 15;19(R2):R188-96. Epub 2010 Sep 15. PubMed | View Abstract
Ding L, Ellis MJ, Li S, Larson DE, Chen K, Wallis JW, Harris CC, McLellan…
Genome remodelling in a basal-like breast cancer metastasis and xenograft.
Nature. 2010 Apr 15;464(7291):989-90. PubMed | View Abstract
Wendl MC, Wilson RK.
Statistical aspects of discerning indel-type structural variation via DNA sequence alignment.
BMC Genomics. 2009 Oct 20;10(1):485. [Epub ahead of print] PubMed | View Abstract
Chen K, Wallis JW, McLellan MD, Larson DE, Kalicki JM, Pohl CS, McGrath SD, Wendl…
BreakDancer: an algorithm for high-resolution mapping of genomic structural variation.
Nat Methods. 2009 Sep;6(9):677-81. Epub 2009 Aug 9. PubMed | View Abstract
Wendl MC
Technology takes on deadlines for fetal human rights.
Nature. 2009 Apr 16;458(7240):831. PubMed | View Abstract
