Richard K. Wilson, Ph.D.
Richard K. Wilson, Ph.D.
Director
Mailing Address
Email Richard K. Wilson
Assistant: Josh Peck
Email Josh Peck
Phone: +1-314-286-1809
Dr. Wilson is an expert in molecular genetics and large-scale DNA sequence analysis, and his laboratory at the Washington University School of Medicine is among the world’s leaders in genome analysis. They have sequenced and analyzed billions of bases of DNA from the genomes of bacteria, yeast, roundworms, plants, vertebrates, primates and humans. Dr. Wilson and his colleagues at The Genome Institute sequenced the first animal genome – that of the roundworm Caenorhabditis elegans – and contributed substantially to the sequencing and analysis of the human genome. More recently, Dr. Wilson’s laboratory was the first to sequence the genome of a cancer patient and discover genetic signatures relevant to the pathogenesis of the disease. Building upon this achievement, their current focus is to utilize genome sequencing and analysis technology to discover clues that will facilitate more effective diagnosis and treatment of cancer and other human diseases.
Dr. Wilson is Professor of Genetics, Professor of Molecular Microbiology and Research Member at the Siteman Cancer Center, where he is also a member of the Senior Leadership Committee. Dr. Wilson received his A.B. degree from Miami University in Ohio (Microbiology, 1981), his Ph.D. from the University of Oklahoma (Chemistry and Biochemistry, 1986) and was a Research Fellow in the Division of Biology at the California Institute of Technology.
Selected Publications
Chen K, Wallis JW, Kandoth C, Kalicki-Veizer JM, Mungall KL, Mungall AJ, Jones SJ, Marra…
BreakFusion: Targeted Assembly-based Identification of Gene Fusions in Whole Transcriptome Paired-end Sequencing Data.
Bioinformatics. 2012 May 4. [Epub ahead of print] PubMed | View Abstract
Jasinska AJ, Lin MK, Service S, Choi OW, Deyoung J, Grujic O, Kong SY, Jung…
A non-human primate system for large-scale genetic studies of complex traits.
Hum Mol Genet. 2012 May 3. [Epub ahead of print] PubMed | View Abstract
Dennis MY, Nuttle X, Sudmant PH, Antonacci F, Graves TA, Nefedov M, Rosenfeld JA, Sajjadian…
Evolution of Human-Specific Neural SRGAP2 Genes by Incomplete Segmental Duplication.
Cell. 2012 May 2. [Epub ahead of print] PubMed | View Abstract
Iossifov I, Ronemus M, Levy D, Wang Z, Hakker I, Rosenbaum J, Yamrom B, Lee…
De novo gene disruptions in children on the autistic spectrum.
Neuron. 2012 Apr 26;74(2):285-99. PubMed | View Abstract
Young MA, Larson DE, Sun CW, George DR, Ding L, Miller CA, Lin L, Pawlik…
Background Mutations in Parental Cells Account for Most of the Genetic Heterogeneity of Induced Pluripotent Stem Cells.
Cell Stem Cell. 2012 Apr 26. [Epub ahead of print] PubMed | View Abstract
Itsara A, Vissers LE, Steinberg KM, Meyer KJ, Zody MC, Koolen DA, de Ligt J,…
Resolving the breakpoints of the 17q21.31 microdeletion syndrome with next-generation sequencing.
Am J Hum Genet. 2012 Apr 6;90(4):599-613. PubMed | View Abstract
Ventura M, Catacchio C, Sajjadian S, Vives L, Sudmant P, Marques-Bonet T, Graves TA, Wilson…
The evolution of African great ape subtelomeric heterochromatin and the fusion of human chromosome 2
Genome Res. 2012 Mar 14. [Epub ahead of print] PubMed | View Abstract
Walter MJ, Shen D, Ding L, Shao J, Koboldt DC, Chen K, Larson DE, McLellan…
Clonal Architecture of Secondary Acute Myeloid Leukemia.
N Engl J Med. 2012 Mar 14. [Epub ahead of print] PubMed | View Abstract
Cheung NK, Zhang J, Lu C, Parker M, Bahrami A, Tickoo SK, Heguy A, Pappo…
Association of age at diagnosis and genetic mutations in patients with neuroblastoma.
JAMA. 2012 Mar 14;307(10):1062-71. PubMed | View Abstract
Scally A, Dutheil JY, Hillier LW, Jordan GE, Goodhead I, Herrero J, Hobolth A, Lappalainen…
Insights into hominid evolution from the gorilla genome sequence.
Nature. 2012 Mar 7;483(7388):169-75. doi: 10.1038/nature10842. PubMed | View Abstract
Hughes JF, Skaletsky H, Brown LG, Pyntikova T, Graves T, Fulton RS, Dugan S, Ding…
Strict evolutionary conservation followed rapid gene loss on human and rhesus Y chromosomes.
Nature. 2012 Feb 22. doi: 10.1038/nature10843. [Epub ahead of print] PubMed | View Abstract
Koboldt DC, Zhang Q, Larson DE, Shen D, McLellan MD, Lin L, Miller CA, Mardis…
VarScan 2: Somatic mutation and copy number alteration discovery in cancer by exome sequencing.
Genome Res. 2012 Feb 2. [Epub ahead of print] PubMed | View Abstract
St. Jude Children's Research Hospital-Washington University Pediatric Cancer Genome Project, Wu G, Broniscer A, McEachron…
Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas.
Nat Genet. 2012 Jan 29 [Epub ahead of print] PubMed | View Abstract
Maher CA, Wilson RK.
Chromothripsis and human disease: piecing together the shattering process.
Cell. 2012 Jan 20;148(1-2):29-32. PubMed | View Abstract
Koboldt DC, Larson DE, Chen K, Ding L, Wilson RK.
Massively parallel sequencing approaches for characterization of structural variation.
Methods Mol Biol. 2012;838:369-84. PubMed | View Abstract
