Richard K. Wilson, Ph.D.
Richard K. Wilson, Ph.D.
Director
Mailing Address
Email Richard K. Wilson
Assistant: Josh Peck
Email Josh Peck
Phone: +1-314-286-1809
Dr. Wilson is an expert in molecular genetics and large-scale DNA sequence analysis, and his laboratory at the Washington University School of Medicine is among the world’s leaders in genome analysis. They have sequenced and analyzed billions of bases of DNA from the genomes of bacteria, yeast, roundworms, plants, vertebrates, primates and humans. Dr. Wilson and his colleagues at The Genome Institute sequenced the first animal genome – that of the roundworm Caenorhabditis elegans – and contributed substantially to the sequencing and analysis of the human genome. More recently, Dr. Wilson’s laboratory was the first to sequence the genome of a cancer patient and discover genetic signatures relevant to the pathogenesis of the disease. Building upon this achievement, their current focus is to utilize genome sequencing and analysis technology to discover clues that will facilitate more effective diagnosis and treatment of cancer and other human diseases.
Dr. Wilson is Professor of Genetics, Professor of Molecular Microbiology and Research Member at the Siteman Cancer Center, where he is also a member of the Senior Leadership Committee. Dr. Wilson received his A.B. degree from Miami University in Ohio (Microbiology, 1981), his Ph.D. from the University of Oklahoma (Chemistry and Biochemistry, 1986) and was a Research Fellow in the Division of Biology at the California Institute of Technology.
Selected Publications
Koboldt DC, Zhang Q, Larson DE, Shen D, McLellan MD, Lin L, Miller CA, Mardis…
VarScan 2: Somatic mutation and copy number alteration discovery in cancer by exome sequencing.
Genome Res. 2012 Feb 2. [Epub ahead of print] PubMed | View Abstract
St. Jude Children's Research Hospital-Washington University Pediatric Cancer Genome Project, Wu G, Broniscer A, McEachron…
Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas.
Nat Genet. 2012 Jan 29 [Epub ahead of print] PubMed | View Abstract
Maher CA, Wilson RK.
Chromothripsis and human disease: piecing together the shattering process.
Cell. 2012 Jan 20;148(1-2):29-32. PubMed | View Abstract
Koboldt DC, Larson DE, Chen K, Ding L, Wilson RK.
Massively parallel sequencing approaches for characterization of structural variation.
Methods Mol Biol. 2012;838:369-84. PubMed | View Abstract
Ding L, Ley TJ, Larson DE, Miller CA, Koboldt DC, Welch JS, Ritchey JK, Young…
Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing.
Nature. 2012 Jan 11. doi: 10.1038/nature10738. [Epub ahead of print] PubMed | View Abstract
Zhang J, Ding L, Holmfeldt L, Wu G, Heatley SL, Payne-Turner D, Easton J, Chen…
The genetic basis of early T-cell precursor acute lymphoblastic leukaemia.
Nature. 2012 Jan 11;481(7380):157-63. doi: 10.1038/nature10725. PubMed | View Abstract
Zhang J, Benavente CA, McEvoy J, Flores-Otero J, Ding L, Chen X, Ulyanov A, Wu…
A novel retinoblastoma therapy from genomic and epigenetic analyses.
Nature. 2012 Jan 11. doi: 10.1038/nature10733. [Epub ahead of print] PubMed | View Abstract
Graubert T, Shen D, Ding L, Okeyo-Owuor T, Lunn CL, Shao J, Krysiak K, Harris…
Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes
Nature Genetics. 2011 Dec 11. [Advanced online publication] PubMed | View Abstract
Larson DE, Harris CC, Chen K, Koboldt DC, Abbott TE, Dooling DJ, Ley TJ, Mardis…
SomaticSniper: Identification of Somatic Point Mutations in Whole Genome Sequencing Data.
Bioinformatics. 2011 Dec 6. [Epub ahead of print] PubMed | View Abstract
Lindblad-Toh K, Garber M, Zuk O, Lin MF, Parker BJ, Washietl S, Kheradpour P, Ernst…
A high-resolution map of human evolutionary constraint using 29 mammals.
Nature. 2011 Oct 12;478(7370):476-82. doi: 10.1038/nature10530. PubMed | View Abstract
Marth GT, Yu F, Indap AR, Garimella K, Gravel S, Leong WF, Tyler-Smith C, Bainbridge…
The functional spectrum of low-frequency coding variation.
Genome Biol. 2011 Sep 14;12(9):R84. [Epub ahead of print] PubMed | View Abstract
Gravel S, Henn BM, Gutenkunst RN, Indap AR, Marth GT, Clark AG, Yu F, Gibbs…
Demographic history and rare allele sharing among human populations.
Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):11983-11988. Epub 2011 Jul 5. PubMed | View Abstract
Church DM, Schneider VA, Graves T, Auger K, Cunningham F, Bouk N, Chen HC, Agarwala…
Modernizing reference genome assemblies.
PLoS Biol. 2011 Jul;9(7):e1001091. Epub 2011 Jul 5. PubMed | View Abstract
The Cancer Genome Atlas Research Network
Integrated genomic analyses of ovarian carcinoma
Nature. 2011 Jun 29;474(7353):609-15. doi: 10.1038/nature10166. PubMed | View Abstract
Ventura M, Catacchio CR, Alkan C, Marques-Bonet T, Sajjadian S, Graves TA, Hormozdiari F, Navarro…
Gorilla genome structural variation reveals evolutionary parallelisms with chimpanzee.
Genome Res. 2011 Jul 20. [Epub ahead of print] PubMed | View Abstract
