Projects: Cancer Genomics

Acute Myeloid Leukemia (AML) cells.

A major goal of the McDonnell Genome Institute is to advance the emerging field of cancer genomics. In 2008, the McDonnell Genome Institute became the first to sequence the complete genome of a cancer patient — a woman with leukemia — and to trace her disease to its genetic roots. We have since sequenced the genomes of many cancer patients including those with breast, lung, ovarian and brain tumors. The McDonnell Genome Institute has also initiated a major landmark project with St. Jude Children’s Research Hospital to sequence the genomes of several hundred pediatric cancer patients.

See below for a list of our cancer genomics projects.

Human Cancer Genome Sequencing Progress

  • AML: Acute Myeloid Leukemia
  • BRC: Breast
  • EMC: Endometrial
  • ESC: Esophageal
  • GBM: Glioblastoma Multiforme
  • GIA: Gastrointestinal Adenocarcinoma
  • HCC: Hepatocellular Carcinoma
  • LUC: Lung
  • MDS: Myelodysplastic Syndrome
  • MEL: Melanoma
  • MMY: Multiple Myeloma
  • OVC: Ovarian
  • PCA: Pilocytic Astrocytoma
  • PNC: Pancreatic
  • PRC: Prostate
  • SJACT: Adrenocortical Tumor
  • SJAMLM7: Acute Myeloid Leukemia M7
  • SJBALL: B-cell precursor Acute Lymphoblastic Leukemia (ALL)
  • SJCBF: Core Binding Factor Acute Myeloid Leukemia
  • SJCPC: Choroid Plexus Carcinoma
  • SJE2A: E2A-PBX (ALL)
  • SJEPD: Ependymoma
  • SJERG: ETS-Related Gene-Associated ALL
  • SJETV: ETV-associated ALL
  • SJEWS: Ewing's Sarcoma
  • SJHGG: High Grade Glioma
  • SJHYPER: Hyperdiploid ALL
  • SJHYPO: Hypodiploid ALL
  • SJINF: Infant ALL
  • SJLGG: Low Grade Glioma
  • SJMB: Medulloblastoma
  • SJMEL: Melanoma
  • SJNBL: Neuroblastoma
  • SJOS: Osteosarcoma
  • SJPHALL: Ph+ ALL
  • SJRB: Retinoblastoma
  • SJRHB: Rhabdomyosarcoma
  • SJTALL: T-cell ALL
  • Sample Intake: Samples arrive at The McDonnell Genome Institute. The samples are then entered into the database. This process includes assigning barcodes to each sample and connecting each sample and its associated data with a specific project.
  • Resource Bank: Samples are stored in a central location at The McDonnell Genome Institute. At this point they are held until they are needed or they undergo a quality control process that assesses the sample quality and quantity. After this assessment the samples are checked out to the appropriate group for processing.
  • Library Construction: DNA samples have libraries prepared for sequencing. These libraries are made for the Illumina platform.
  • Library Complete: DNA sample libraries are complete and ready to be sequenced.
  • Data Generation: Libraries either go to the sequence queue to wait for a production slot or sequence data is actively generated on the machines.
  • Coverage/Quality Check: Sequence data generation is completed and the analysis group reviews the data to ensure that each genome has complete coverage and is ready for processing in the analysis pipeline.
  • Complete: Cancer genome sequencing and validation are complete.