Center Initiated Projects
Center Initiated Projects (CIPs) are proposed by The Genome Institute to help fulfill the mission and strategic vision of the NHGRI and NIH. All CIP data will be released in a timely manner via appropriate databases in accordance with NHGRI and NIH guidelines.
Cancer Genomics: Comparing Breast Cancer and Xenotransplant Whole Genomes
This project proposes to explore the relatedness of primary breast cancer disease genomes to their matched xenotransplants to help develop model systems for studying the basic biology and treatment of tumors.
Cancer Genomics: Expanding the Clinical Trial Z1031 for Breast Cancer Tumor Sequencing
Previously, we sequenced 50 tumor/normal pairs from the ACOSOG Z1031 breast cancer trial. We propose to sequence additional breast cancer patients to include a more complete spectrum of clinically important estrogen receptor positive breast cancer subtypes.
Cancer Genomics: Sequencing Aggressive Germline Prostate Cancer
This project will search for genetic determinants of susceptibility to aggressive prostate carcinoma in Caucasians and African Americans. We will also sequence a representative subset of therapy-resistant tumors and produce a rich resource of coding SNPs for African Americans, a currently under-represented ethnic group in dbSNP.
Cancer Genomics: Treatment-Associated Acute Myeloid Leukemia (AML)
Treatment-associated AML, which develops as a consequence of treatment for a primary cancer diagnosis and ensuing treatment, is emerging as a major clinical problem. This project is aimed at identifying relevant mutations that contribute to the disease’s pathogenesis.
Cancer Genomics: Mouse Acute Promyelocytic Leukemia (APL) as a model for Acute Myeloid Leukemia (AML)
This project will sequence the genomes of APL tumors arising in a well-defined mouse model, define recurring mutations in a set of mouse APL tumors, and compare these mutations to those found in human APL tumors.
Cancer Genomics: Mouse Luminal Mammary Tumors
We propose to use whole genome sequencing and analysis to characterize the genomes of a series of mouse mammary tumors. Results from the mutational analyses of these murine tumors will be further compared to the large amount of available data from human luminal breast cancers.
Cancer Genomics: Breast Cancer Knock-Out Mouse Models
We propose whole genome sequencing and analysis of mouse models and types of mouse tissues that have developed breast cancers representing major subtypes of the human disease. These data will be analyzed and compared to corresponding subtype tumors from human patients.
Cancer Genomics: Inducible Mouse Model of Colon Cancer
We will conduct whole genome sequencing and analysis of mice with serially biopsied colon cancer tumors with known initiating mutations that are sampled as the tumor grows and metastasizes. These data will help build a model that then could be investigated and compared to human colon cancer.
Human Genetics: Sequencing Spontaneous Amyotrophic Lateral Sclerosis
The majority of Amyotrophic Lateral Sclerosis (ALS) cases arise spontaneously and for no known reason. This project aims to detect gene expression changes that are specific to tissues affected by this spontaneous form of ALS compared to unaffected tissues.
Pathogen Genomics and Global Health: Drug-Resistance in Parasitic Worms
Helminth (parasitic worm) infections have a high disease burden. Reinfection after helminth parasite drug therapy is common and anthelmintic resistance is emerging and spreading as a problem. This proposal seeks to sequence anthelmintic resistant strains to better understand the genome diversity and mechanisms of resistance in human helminths.
Research Areas
