EGFR FGFR1 PDGFR VEGFR NTRK EPHA/B INSR RAS PI3K RAF AKT CDK MAPK NF1 PTEN CDKN2A MDM2 RB1 CTNNB1 APC TSC1/2 ATM TP53 STK11 TSP Sample ID EGFR(copy number) EGFR(mutations) ERBB2(mutations) ERBB3(mutations) ERBB4(mutations) FGFR1(copy number) FGFR1(mutations) FGFR2(mutations) FGFR4 (copy number) FGFR4(mutations) PDGFRA(mutations) PDGFRB(mutations) KDR(copy number) FLT1(mutations) FLT4(mutations) KDR(mutations) NTRK1(mutations) NTRK2(mutations) NTRK3(mutations) EPHA3(copy number) EPHA1(mutations) EPHA2(mutations) EPHA3(mutations) EPHA4(mutations) EPHA5(mutations) EPHA6(mutations) EPHA7(mutations) EPHB1(mutations) EPHB4(mutations) EPHB6(mutations) INSR(mutations) INSRR(mutations) IGF1R(mutations) KRAS(copy number) KRAS(mutations) NRAS (copy number) NRAS(mutations) MRAS(mutations) ERAS(mutations) HRAS(mutations) PIK3C2A(mutations) PIK3C2B(mutations) PIK3C2G(mutations) PIK3C3(mutations) PIK3CA(mutations) PIK3CD(mutations) PIK3CG(mutations) PIK3R2(mutations) ARAF(mutations) BRAF(mutations) AKT1(mutations) AKT3(mutations) CDK6(copy number) CDK5(mutations) CDK7(mutations) CDK9(mutations) MAP2K5(mutations) MAP2K6(mutations) MAP3K10(mutations) MAP3K12(mutations) MAP3K15(mutations) MAP3K2(mutations) MAP3K4(mutations) MAP3K6(mutations) MAP3K9(mutations) MAP4K1(mutations) MAP4K3(mutations) MAP4K4(mutations) MAPK4(mutations) MAPK6(mutations) MAPK7(mutations) MAPK8(mutations) NF1(copy number) NF1(mutations) PTEN(copy number) PTEN(mutations) CDKN2A(copy number) CDKN2A(mutations) MDM2(copy number) MDM2(mutations) RB1(mutations) CTNNB1(mutations) APC (copy number) APC(mutations) TSC1(mutations) TSC2(mutations) ATM(copy number) ATM(mutations) TP53(copy number) TP53(mutations) STK11(mutations) STK11(LOH) 16530 2.0718702820464 0 0 0 0 1.60837464693601 0 0 1.60421832749824 0 0 0 2.13949985324139 0 0 0 0 0 0 2.20709679162412 0 0 0 0 0 0 0 0 0 0 0 0 0 1.95192296997881 0 1.98270402452134 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2.08923215028468 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.69170768195296 0 2.11444171097915 0 2.28320690023532 0 1.64025213617979 0 0 0 1.99809738477328 0 0 0 1.77225340271418 0 1.64356509853708 0 0 NO 16594 2.10678222122637 0 0 0 0 1.70445628681077 0 0 1.61409881165026 0 0 0 2.02718558380734 0 0 0 0 0 0 2.17142692106764 0 0 0 0 0 0 0 0 0 0 0 0 0 1.93365104052281 0 1.79595860770839 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2.18189291885654 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.85305448336873 0 2.05622193799379 0 2.12585734719207 0 1.72397242660928 0 0 0 1.93638302203963 0 0 0 1.73113543734091 0 1.5544659334873 0 0 NO 16596 2.13899529631962 0 0 0 0 1.77437297810248 0 0 1.62399591097917 0 0 0 2.06653225232637 0 0 0 0 0 0 2.03659739620282 0 0 0 0 1 0 0 0 0 0 0 0 0 1.82653702716583 1 1.9625872190131 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.95468691837666 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.69936599337604 0 2.04003475380746 0 1.89077112789326 0 1.64355233918245 0 0 0 1.99469087816499 0 0 0 1.83015038392439 0 1.81017389879064 0 1 NO 16600 2.02689878733373 0 0 0 1 1.99596052896351 0 0 2.1208256590013 0 0 0 2.43046389031917 0 0 0 0 0 0 2.00030883158519 0 0 0 0 0 0 0 0 0 0 0 0 0 2.06822433560389 1 1.67948487139351 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2.02869496855389 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 2.4984455898853 0 1.57945430581656 1 1.9921690061663 0 1.72470509679603 0 1 0 1.59092497222632 0 0 0 2.02680266367441 0 1.76964833985971 1 0 NO 16606 2.04984738163972 0 0 0 0 1.98156381619697 0 0 2.05123566280695 0 0 0 2.16565119842696 0 0 0 0 0 0 1.90416408045414 0 0 0 0 0 0 0 0 0 0 0 0 0 1.92704495782321 0 2.27584609797266 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2.15078065411192 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2.17490652966185 0 1.70578734294944 0 1.63078353949396 0 6.62165111834946 0 0 0 1.74435418013077 0 0 0 2.03960999083434 0 1.66228908521311 0 0 NO 16608 2.06624838228819 0 0 0 0 1.48867910023985 0 0 1.777816596221 0 1 0 2.10411523772249 0 0 0 0 0 0 2.10217811167989 0 0 0 0 0 0 0 0 0 0 0 1 0 1.94991178879188 1 2.42109048645855 0 0 0 0 0 0 0 0 0 0 0 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2.02985295412168 0 1.9455995092571 0 0 0 1.76896291094117 0 0 0 1.90722620042479 0 1.78261135399402 1 1 NO 16636 2.12094791141086 0 0 0 0 1.93985399412408 0 0 1.97360107968965 0 0 0 1.9916313279631 0 0 0 0 0 0 1.95287745294485 0 0 0 0 0 0 0 0 0 0 0 0 0 2.06805902131953 0 1.90301572112299 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2.0843398397338 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.99714430853688 0 1.90887086789816 0 1.96947327463935 0 2.06848048989474 0 0 0 1.88052728640513 0 0 0 2.01892385565429 0 2.07155538118856 0 1 NO 16638 2.22905173329622 1 0 0 0 2.41364834693505 0 0 2.74428953421102 0 0 0 1.7768001256246 0 0 0 0 0 0 1.87231618659073 0 0 0 0 0 0 0 0 0 0 0 0 0 2.24340003571869 0 1.79665686294372 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.84179501025008 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.89793023226352 0 1.80753978239243 0 1.64307632655647 0 2.4864063614737 0 0 0 2.44289118109759 0 0 0 2.69361638112577 0 1.93699568488355 0 0 NO 16640 2.29381636690097 0 0 0 0 2.36837035384033 0 0 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2.04638235542584 0 1.53566549873791 0 2.65274242481786 0 1 0 1.69367915364157 0 0 0 2.19892302130865 0 1.60614161252076 1 1 YES 17766 2.02275782031194 0 0 0 0 2.09496739393656 0 0 2.35011165240384 0 0 0 1.94009972268111 0 0 0 0 0 0 2.0205606826136 0 0 0 0 0 0 0 0 0 0 0 0 0 1.96592831956046 1 2.02819829479488 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.90576362433567 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 1.94051249137317 0 1.97125659270724 0 1.99928013473229 0 1.79775771377224 0 0 0 2.09237395910007 0 0 0 2.02264209685702 0 2.02827504104863 0 0 NO 17769 2.01487232024348 0 0 0 0 1.9593224165406 0 0 2.16796730552834 0 0 0 2.05365541408087 0 0 0 0 0 0 2.01237837690908 0 0 0 0 0 0 0 0 0 0 0 0 0 2.08612704418108 0 1.87060601277453 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2.0864007307826 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.98836212540294 0 1.9944181816553 0 2.05923174593098 0 2.03242489386513 0 0 0 2.00578825355942 0 0 0 1.37137687508482 0 2.05556143403331 0 0 NO 17776 1.86516323821253 0 0 0 0 3.22376995888016 0 0 2.33235549620796 0 0 0 3.16525888102443 0 0 0 0 0 1 1.91101326156615 0 0 0 0 0 0 0 0 0 0 0 0 0 2.02285816887075 0 1.69112968772697 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 1.96596816465937 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.89417002998969 0 1.85203004082394 0 1.95016897008935 0 2.13223133379736 0 0 0 2.25961988221452 0 0 0 2.06106312278764 0 1.90734478647649 0 1 NO 17777 1.87605621750968 0 0 0 0 1.79460147244211 0 0 2.55096375365276 0 0 0 2.1191254554808 0 0 0 0 0 0 1.79935119825104 0 0 0 0 0 0 0 0 0 0 0 0 0 1.99985818850101 1 1.69126777873374 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.65131471296492 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2.23982543885351 0 2.24348400763633 0 2.01843593987377 0 1.80043760109518 0 0 0 2.11071820192412 0 0 0 2.12062644795086 0 2.06862976418215 1 0 NO 17778 2.68632191448316 0 0 0 0 2.04763072577283 0 0 2.34865791778129 0 0 0 1.95798123712552 0 0 0 0 0 0 1.9072349255686 0 0 0 0 0 0 0 0 0 0 0 0 0 1.97805461483239 0 1.97906184937289 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.56185573366682 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.88878420217184 0 1.93335805869588 0 1.9232495622852 0 1.97797584768354 0 0 0 1.51175264168164 1 0 0 2.31348236227002 0 2.04946572112328 0 1 YES 17781 2.06572650636917 0 0 0 0 2.39160295737573 0 0 1.97897981856077 0 0 0 1.90637850512523 0 0 0 0 0 0 2.09185357537363 0 0 0 0 1 0 0 0 0 0 0 0 0 1.99600716295447 1 1.69501483490627 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2.06120543254784 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2.20368436400422 0 2.01432005339681 0 1.76502094053637 0 2.13335188478076 0 0 0 2.05778871494231 0 0 0 1.93806977224555 0 1.82438966171659 0 1 NO 17784 2.28950402293014 0 0 0 0 2.26028124937461 0 0 1.90895736276517 0 0 0 1.94510081183385 0 0 0 0 0 0 2.33126369419289 0 0 0 0 0 0 0 0 0 0 0 0 0 1.96956064520752 0 2.08092847777162 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.89051693126024 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2.26186778400214 2 1.86456384804829 0 1.54283266897889 0 2.13545065316521 0 0 0 1.90416609985014 0 0 0 2.22523329938704 0 2.40805993456867 0 0 NO Number of samples with alterations 51 35 8 16 19 30 10 71 15 4 3 10 25 14 4 29 17 7 2 14 4 15 68 44 Percentage of samples altered 0.271276595744681 0.186170212765957 0.0425531914893617 0.0851063829787234 0.101063829787234 0.159574468085106 0.0531914893617021 0.377659574468085 0.0797872340425532 0.0212765957446809 0.0159574468085106 0.0531914893617021 0.132978723404255 0.074468085106383 0.0212765957446809 0.154255319148936 0.0904255319148936 0.0372340425531915 0.0106382978723404 0.074468085106383 0.0212765957446809 0.0797872340425532 0.361702127659574 0.234042553191489