Publication

Abstract

Advances in reconstructing the clonal architecture of tumors greatly enhance our understanding of the molecular events within a patient and their context relative to one another. In the rapidly unfolding era of personalized medicine, the ability to monitor clonal evolution throughout patient care has significant clinical implications for the appropriate development or application of targeted therapies as well as understanding the potential mechanisms driving resistance. In this review, we discuss advances in biotechnology and bioinformatics that improve precision treatment by dissecting clonal evolution, focusing first on the initial discoveries in lymphomas and leukemias followed by the more recent applications to advance our understanding of prostate cancer (PCa). Teaser: The ability to monitor clonal evolution throughout patient care has significant clinical implications for the development and application of personalized therapy.

Authors

Dang HX, Maher CA.