Publication

Comprehensive genomic characterization defines human glioblastoma genes and core pathways.

Nature. 2008 Oct 23;455(7216):1061-8. Epub 2008 Sep 4.

Abstract

Human cancer cells typically harbour multiple chromosomal aberrations, nucleotide substitutions and epigenetic modifications that drive malignant transformation. The Cancer Genome Atlas (TCGA) pilot project aims to assess the value of large-scale multi-dimensional analysis of these molecular characteristics in human cancer and to provide the data rapidly to the research community.