Genomic analysis to define molecular basis of aggressiveness in a mouse model of oral cancer.

Genom Data. 2015 Mar 1;3:61-62.


To investigate the molecular basis underlying aggressive behavior in oral squamous cell carcinoma (OSCC), our laboratory developed a carcinogen-induced mouse oral cancer (MOC) cell line model that encompasses the growth and metastasis spectrum of its human counterpart. We performed next-generation sequencing (NGS) and gene expression microarray profiles to explore the genomic and transcriptional backgrounds of the differential MOC line phenotypes, as well as, the cross-species relevance of the model. Here we describe the comparative analysis of NGS ( and expression microarray ( data from the MOC lines and corresponding human data, as described in our recent publication [1].


Chalivendra V, Kanchi KL, Onken MD, Winkler AE, Mardis E, Uppaluri R.

Institute Authors

Krishna Kanchi