Toward a Complete Human Genome Sequence

Genome Res. 1998 Nov;8(11):1097-108.


We have begun a joint program as part of a coordinated international effort to determine a complete human genome sequence. Our strategy is to map large-insert bacterial clones and to sequence each clone by a random shotgun approach followed by directed finishing. As of September 1998, we have identified the map positions of bacterial clones covering ?860 Mb for sequencing and completed >98 Mb (?3.3%) of the human genome sequence. Our progress and sequencing data can be accessed via the World Wide Web ( or


The Sanger Center and The Washington University Genome Sequencing Center

Institute Authors

Robert Waterston