Transcriptome-wide identification of novel imprinted genes in neonatal mouse brain.

PLoS ONE. 2008;3(12):e3839. Epub 2008 Dec 4.


Imprinted genes display differential allelic expression in a manner that depends on the sex of the transmitting parent. The degree of imprinting is often tissue-specific and/or developmental stage-specific, and may be altered in some diseases including cancer. Here we applied Illumina/Solexa sequencing of the transcriptomes of reciprocal F1 mouse neonatal brains and identified 26 genes with parent-of-origin dependent differential allelic expression. Allele-specific Pyrosequencing verified 17 of them, including three novel imprinted genes.


Wang X, Sun Q, McGrath SD, Mardis ER, Soloway PD, Clark AG.

Institute Authors