EXOR
Filters mutually exclusive alignment events and defines a position-specific reciprocal best alignment set.
Package
- category: alignment analysis
- operating system: OS independent (Perl)
- license: GNU GPL
- project administrator: Jarret Glasscock
- download: EXOR
Overview:
Alignment algorithms such as BLAST typically return multiple hits between a given sequence and a collection of sequences. Correctly assigning the best association between them, while avoiding spurious matches (often pseudogenes or paralogs) that are "attractive" to standard alignment tools, is an important starting point for making accurate biological inferences.
With the move towards representing genomes and transcriptomes with only draft-quality coverage, resarchers must wrestle with fragmented and incomplete representations of the underlying data, a scenario which most existing alignment techniques are not designed to handle.
To overcome these problems, EXOR applies multi-stage filtering to exclude lower scoring alignments and picks the highest-scoring mutually exclusive alignments. This approach defines position-specific reciprocal best alignments between two sequence sets, eliminating redundant and competing alignments and simplifying further analyses.
Publication:
Currently under review...
Associated data:
Processed datasets from publication
