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GSC Application: Bioinformatics
Semblance will compare a genome assembly to finished clones and produce
an evaluation of the assembly in terms of a number of metrics, such as:
- Discrepancies (substitutions, deletions, insertions)
- Coverage (of the clone by the assembly)
- Interruptions (of a supercontig by another supercontig)
There are three major phases to semblance: BLASTs of each finished clone against the
assembly contigs, refining those alignments with cross_match, and then analyzing the
alignments according to the various analysis metrics. See this
presentation for more details.
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