Funded Pilot Project

The McDonnell Genome Institute at (MGI) has awarded 9 pilot project grants to support novel collaborations with WU investigators. A committee of 5 faculty members reviewed the 48 submissions from a variety of departments and awarded nine grants. 

  • Luigi Adamo, Kory Lavine, Douglass Mann – Cardiology

Characterization of myocardial B cells heterogeneity and clonal expansion in aging and disease

  • Maxim Artyomov – Immunobiology

Dissecting itaconate-mediated regulation of inflammatory responses at the single-cell level 

  • Joshua Blodgett – Biology

Comparative actinomycete genome analyses to support drug discovery

  • Grant Challen – Oncology

Quantifying the incidence of clonal hematopoiesis in human conditions of increased inflammation 

  • Matthew Christopher – Oncology

Comparison of phased sequencing and optical mapping with short-read whole genome sequencing for the detection of structural variants in chemotherapy-refractory acute myeloid leukemia 

  • Audrey Odom John – Pediatrics

A gold standard genome of the deer malaria parasite, Plasmodium odocoilei 

  • Andrew Malone, Benjamin Humphreys – Nephrology

Defining host-donor chimerism in kidney rejection by scRNA-seq and developing a searchable graphical user interface web tool 

  • Hani Suleiman – Nephrology

Altered tropomyosin isoform repertoire as a regulator of podocyte shape in kidney diseases  

  • Jose Zevallos – Surgery

The effect of tobacco exposure on genomic heterogeneity in HPV-positive oropharyngeal squamous cell carcinoma 

These grants were made possible with funding from the Dean of the School of Medicine, the Dean of Arts and Sciences, the ICTS grant, and Illumina, Inc. Recipients of these grants will present their work at the 2019 MGI symposium.

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