This conference, presented by Genome Engineering and iPSC Center, has a lot of talented participants sharing their work through a virtual poster session. Check out the links below to see all of the unique research.
A zebrafish mutant model to study OCA4
Submitted by Velanganni Selvaraj , email: velu100170@gmail.com
Authors: Velanganni Selvaraj, Hemagowri Venkatasubramanian, Kirankumar Santhakumar
![](https://genome.wustl.edu/files/2021/01/Screen-Shot-2021-01-21-at-7.13.41-AM-1024x723.png)
Paradigm shifting methods for high-throughput functional testing of all possible genetic variants: SLC2A1 and GLUT1 deficiency syndrome as a proof-of-principle
Submitted by Naeimeh Tayebi, email: ntayebi@wustl.edu
Authors:Naeimeh Tayebi, Kevin McCall, Brian Leon Ricardo, Paul Hruz, Ashley Quiggle, Gabe Haller, Matthew B. Dobbs, Christina A. Gurnett
![](https://genome.wustl.edu/files/2021/01/Tayebi-1024x578.png)
CRISPR Prime Design and Testing at the Genome Engineering and iPSC Center
Submitted by: Zi Wang, email: ztwang@wustl.edu
Authors: Wang, Z.T., Sentmanat, M., Chen, Y.H., Cui, X.C.
![](https://genome.wustl.edu/files/2021/01/Screen-Shot-2021-01-21-at-2.54.46-PM-1024x612.png)
Hallmarks of Functional Genomics
Submitted by: William Buchser, email: wbuchser@wustl.edu
Author: William Buchser
![](https://genome.wustl.edu/files/2021/01/Screen-Shot-2021-01-20-at-4.41.35-PM-1024x572.png)
iPSC Differentiation
Submitted by Yong Miao, email: ymiao@wustl.edu
Authors: Yong Miao, Xiaoxia Cui
![](https://genome.wustl.edu/files/2021/01/Screen-Shot-2021-01-20-at-5.29.00-PM-1024x575.png)
Did you miss the talks? Check out the recordings here.
Day 1
January 21, 2021 8 AM to 1 PM
- Charlie Gersbach, Ph.D., Rooney Family Associate Professor of Biomedical Engineering, Duke University
- Decoding and Programming the Genome with CRISPR Technologies
- Ibrahim Kurt, Ph. D. Candidate, Harvard University
- CRISPR C-to-G base editors for inducing targeted DNA transversions in human cells
- Traver Hart, Assistant Professor, Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center
- CRISPR screening for functional genomics and cancer targeting
- Shengdar Tsai, Assistant Member of the Department of Hematology, St. Jude Children’s Research Hospital
- Understanding genetic and epigenetic effects on CRISPR-Cas9 genome-wide activity with CHANGE-seq
- Tim Peterson, Assistant Professor of Medicine, Washington University in St. Louis
- “Sphingolipids connect pathogens to aging-related disease”
- John Doench, Director R&D, Institute Scientist, Broad Institute of MIT and Harvard University
- “Massively parallel variant-to-function mapping with CRISPR base editor screens”
- Andrew Anzalone, Head of the Prime Editing Platform at Prime Medicine, Inc.
- “Prime Editing: Versatile and Precise Genome Editing without Double-strand Breaks or Donor DNA”
- Panel Discussion:
- Including Monica Sentmanat, Ph.D./Assistant Director of GEiC, Steven Hoffman Illumina, Cell & Molecular Biology Segment Manager, and other speakers from the event
- “Off targeting using nucleases, base editors, prime editors, and in screens”
Day 2
January 22, 2021 8 AM to 1 PM
- 8 AM Alejandro Chavez, Assistant Professor of Pathology & Cell Biology, Columbia University
- “Controlling gene expression with CRISPR-based tools”
- 8:30 AM Dongsheng Duan, Margaret Proctor Mulligan Professor in Medical Research, School of Medicine, University of Missouri, Columbia
- “CRISPR editing therapy for Duchenne muscular dystrophy”
- 9 AM Aron Geurts, Associate Professor, Department of Physiology, Medical College of Wisconsin
- Engineering Rats and Rat Model Resources
- 9:30 AM Xiaoxia Cui, Director of the Genome Engineering & iPSC Center, Washington University in St. Louis
- Reliable and Efficient Creation of Floxed Alleles in Mice
- 10 AM Andrew Yoo, Associate Professor of Developmental Biology, Washington University in St. Louis
- “Modeling late-onset neurodegenerative disorders via direct neuronal reprogramming of patient fibroblasts”
- 10:30 AM Martin Kampmann, Associate Professor, Institute for Neurodegenerative Diseases, UCSF Weill Institute for Neurosciences, University of California, San Francisco
- “CRISPR-based functional genomics in iPSC-derived models of brain disease”
- 11 AM. Luke Gilbert, Assistant Professor, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco
- “Genome-wide Programmable Transcriptional Memory by CRISPR-based Epigenome Editing”
- 11:30 AM Michael Kosicki, Postdoctoral Fellow, Lawrence Berkeley National Laboratory
- “Large deletions, small trouble”
- 12 PM Panel Discussion:
- Including Yi-Hsien Chen, Ph.D./Assistant Director of GEiC, Steven Hoffman Illumina, Cell & Molecular Biology Segment Manager, and other speakers from the event
- “On target large deletion, repression as KO alternative, off-targeting potential, continue first days”