Dave Pagliarini, Ph.D.

Hugo F. and Ina C. Urbauer Professor and BJC Investigator

Dave Pagliarini is a BJC Investigator and the Hugo F. and Ina C. Urbauer Professor of Cell Biology & Physiology, Biochemistry & Molecular Biophysics, and Genetics at Washington University School of Medicine in St. Louis. After graduating with honors in from the University of Notre Dame in 1999, Dave earned a Ph.D. in biomedical sciences from UC San Diego in 2005, and completed his postdoctoral work in systems biology at Harvard Medical School/The Broad Institute with Vamsi Mootha in 2009. Prior to joining the WashU faculty in 2020, Dave was a Professor of Biochemistry at UW-Madison and the Arthur C. Nielsen Jr. Chair of Metabolism at the Morgridge Institute for Research. Building upon his work in establishing the mitochondrial proteome — the MitoCarta project— Dave’s lab studies the composition and function of the mitochondrial proteome and its relationship to human disease. In particular, his group blends large-scale genomics, proteomics, and metabolomics analyses with mechanistic biochemistry and cell biology to define the functions of proteins and pathways related to mitochondria, identify causative variants in unresolved rare metabolic diseases, and explore new therapeutic approaches for mitochondrial disorders. Further information on the Pagliarini Lab can be found on their laboratory website.

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